| アブストラクト | BACKGROUND: There is a documented association between drug exposure and sarcoidosis-like reactions. In this study, we used the largest pharmacovigilance database to describe drug-induced sarcoidosis. METHODS: Data were collected from the World Health Organization (WHO) pharmacovigilance database (VigiBase). We excluded steroids and vaccines from the analysis. The primary end-point was the lower end-point of the 95% credibility interval for the information component (IC025 ). RESULTS: A total of 127 reports had significant IC025 values for drug-induced sarcoidosis, and 110 were included in the final analysis, accounting for 2425 adverse drug reactions. Overall, 2074 (85.5%) reactions were considered 'serious' and 86 (3.5%) were fatal. Most of the drugs that led to sarcoidosis adverse reactions were TNF-alpha antagonists, interferon or peg-interferon therapeutics, and immune checkpoint inhibitors. Other biologic drugs were less frequently associated with sarcoidosis adverse events. Cancer-targeted therapies such as BRAF or MEK inhibitors were associated with sarcoidosis reactions in 37 cases. Pulmonary hypertension drugs were also reported for drug-induced sarcoidosis. Amongst the 55 drugs considered as potential sarcoidosis inducers, 25 (45.4%) were never reported in Medline as drug-induced sarcoidosis. CONCLUSIONS: We provide a detailed list of suspected drugs associated with drug-induced sarcoidosis that will improve the recognition of this drug-induced adverse event. |
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| ジャーナル名 | Journal of internal medicine |
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| Pubmed追加日 | 2019/10/16 |
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| 投稿者 | Cohen Aubart, F; Lhote, R; Amoura, A; Valeyre, D; Haroche, J; Amoura, Z; Lebrun-Vignes, B |
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| 組織名 | Assistance Publique-Hopitaux de Paris, Service de Medecine Interne 2, Centre;National de Reference Maladies Systemiques Rares et Histiocytoses, Hopital;Pitie-Salpetriere, Sorbonne Universite, Paris, France.;Service de Pneumologie, Assistance Publique-Hopitaux de Paris, Hopital Avicenne,;Bobigny, France.;Assistance Publique-Hopitaux de Paris, Service de Pharmacovigilance de la;pitie-Salpetriere, Paris, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/31612562/ |
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