| アブストラクト | AIMS: Sweet's syndrome is an acute febrile neutrophilic dermatosis first described in 1964 by Robert Douglas Sweet. The pathophysiological mechanism is not fully established; however, several cases of Sweet's syndrome have been reported following drug administration. METHODS: To investigate the existence of pharmacovigilance signals between drugs and the occurrence of Sweet's syndrome, we performed a case/non-case study on reports of 'acute febrile neutrophilic dermatosis' registered in the French pharmacovigilance database. Reporting odds ratio (ROR) with its 95% confidence interval were calculated. RESULTS: Amongthe 994 789 reports recorded in the database, 136 were Sweet's syndrome, of which 50.7% were men and the median age was 59 years (range 15-91). A total of 224 drugs were mentioned as suspects: 21.0% were antibacterials, 19.2% were antineoplastics and 12.1% were immunosuppressants. Median time to onset from drug initiation to the development of Sweet's syndrome was 15 days (range 1-1095). The highest RORs were observed with bortezomib (74.04 [40.8-134.2]), azacitidine (72.14 [29.4-176.9]), perfilgrastim (67.05 [21.2-211.6]), azathioprine (55.46 [34.8-88.4]) and bendamustine (35.84 [11.4-112.8]). CONCLUSIONS: Pharmacovigilance signals have been observed between the occurrence of Sweet's syndrome and colony-stimulating factors, immunosuppressants, antineoplastics and antibiotics. Clinicians should be aware of the potential associations with these drugs and should be encouraged to report any case of drug-induced Sweet's syndrome. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| 投稿日 | 2023/8/9 |
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| 投稿者 | Martin, Salome; Trenque, Thierry; Herlem, Emmanuelle; Boulay, Charlene; Pizzoglio, Veronique; Azzouz, Brahim |
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| 組織名 | Regional Centre of Pharmacovigilance and Pharmacoepidemiology, Reims University;Hospital, 51100, Reims, France.;Regional Centre of Pharmacovigilance and Pharmacoepidemiology, Rouen University;Hospital, 76000, Rouen, France.;Regional Centre of Pharmacovigilance and Pharmacoepidemiology, Lyon University;Hospital, 69495, Lyon, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37555568/ |
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