| アブストラクト | BACKGROUND: Several case reports have suggested that drugs could induce restless legs syndrome. However, no systematic review of this adverse drug reaction (ADR) in a pharmacovigilance database has been published. OBJECTIVE: To assess the frequency of restless legs syndrome in the French Pharmacovigilance Database. METHODS: We selected all ADR reports from January 1, 1984 to December 31, 2009 coded as restless legs syndrome. Restless legs syndrome diagnosis was validated from case descriptions. Using a case/noncase approach, reporting odds ratio and 95% confidence interval were calculated for "suspected'' drugs with 2 or more observations. RESULTS: Twenty-six ADR reports were found. Four cases were excluded because of alternative diagnosis. Fourteen cases were women (64%). Median age was 57. Most frequently suspected drugs were antidepressants (reporting odds ratio, 15.9 [6.4-39.7]; amitriptyline, escitalopram, mianserine, mirtazapine, duloxetine), neuroleptics (17.8 [6.1-51.7]; thioridazine, loxapine, risperidone, aripiprazole) or tramadol (18.2 [6.3-52.8]). CONCLUSIONS: Restless legs syndrome is a very rare ADR that was more frequently reported in association with antidepressants, neuroleptics, or tramadol. |
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| ジャーナル名 | Journal of clinical psychopharmacology |
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| Pubmed追加日 | 2012/11/8 |
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| 投稿者 | Perez-Lloret, Santiago; Rey, Maria Veronica; Bondon-Guitton, Emmanuelle; Rascol, Olivier; Montastruc, And Jean-Louis |
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| 組織名 | Service de Pharmacologie Medicale et Clinique, Centre Midi-Pyrenees de;Pharmacovigilance, de Pharmacoepidemiologie et d'Informations sur le Medicament,;Centre Hospitalier Universitaire et Universite Paul Sabatier, Faculte de;Medicine, Toulouse, France. splloret@fleni.org.ar |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/23131889/ |
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