| アブストラクト | OBJECTIVE: To investigate the association between duration of type 2 diabetes and cancer incidence. RESEARCH DESIGN AND METHODS: In the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged >/=35 years at diagnosis who were linked to hospital and mortality records. We used sex-stratified Royston-Parmar models with two timescales to estimate incidence rates of all cancers, the four commonest cancers in the U.K. (colorectal, lung, prostate, breast), and the obesity-related cancers (e.g., liver, ovary) between 1 January 1998 and 14 January 2019, by age and diabetes duration. RESULTS: During 1,089,923 person-years, 18,977 incident cancers occurred. At the same age, rates of all cancers in men and women did not vary across durations ranging from diagnosis to 20 years; conversely, for any duration, there was a strong, positive association between age and cancer rates. In men, the rate ratio (95% CI) comparing 20 with 5 years of duration was 1.18 (0.82-1.69) at 60 years of age and 0.90 (0.75-1.08) at 80 years; corresponding ratios in women were 1.07 (0.71-1.63) and 0.84 (0.66-1.05). This pattern was observed also for the four commonest cancers. For obesity-related cancers, although rates were generally higher in individuals with a higher BMI, there was no association with duration at any level of BMI. CONCLUSIONS: In this study, we did not find evidence of an association between duration of type 2 diabetes and risk of cancer, with the higher risk observed for longer durations related to ageing. |
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| ジャーナル名 | Diabetes care |
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| 投稿日 | 2023/8/28 |
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| 投稿者 | Zaccardi, Francesco; Ling, Suping; Brown, Karen; Davies, Melanie; Khunti, Kamlesh |
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| 組織名 | Leicester Real World Evidence Unit, Leicester Diabetes Research Centre, Leicester;General Hospital, University of Leicester, Leicester, U.K.;Leicester Diabetes Research Centre, Leicester General Hospital, University of;Leicester, Leicester, U.K.;Inequalities in Cancer Outcomes Network Group, Department of Noncommunicable;Disease Epidemiology, Faculty of Epidemiology and Population Health, London;School of Hygiene & Tropical Medicine, London, U.K.;Leicester Cancer Research Centre, Leicester Royal Infirmary, University of;National Institute for Health and Care Research, Leicester Biomedical Research;Centre, University Hospitals of Leicester NHS Trust and the University of;National Institute for Health and Care Research, Applied Research Collaboration;East Midlands, University of Leicester, Leicester, U.K. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37639691/ |
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