| アブストラクト | OBJECTIVE: To compare the incidence of venous thromboembolism among women taking combined oral contraceptives before and after the October 1995 pill scare. DESIGN: Analysis of General Practice Research Database. SETTING: United Kingdom, January 1993 to December 1998. SUBJECTS: Women aged 15-49 taking combined oral contraceptives. MAIN OUTCOME MEASURES: Incidence of venous thromboembolism. RESULTS: Use of so called "third generation" combined oral contraceptives fell from 53% during January 1993 to October 1995 to 14% during November 1995 to December 1998. There was no significant change in the incidence of venous thromboembolism between the two periods after age was adjusted for (incidence ratio 1.04, 95% confidence interval 0.78 to 1.39). CONCLUSIONS: The findings are not compatible with the assertion that third generation oral contraceptives are associated with a twofold increase in risk of venous thromboembolism compared with older progestogens. |
|---|
| ジャーナル名 | BMJ (Clinical research ed.) |
|---|
| 投稿日 | 2000/8/19 |
|---|
| 投稿者 | Farmer, R D; Williams, T J; Simpson, E L; Nightingale, A L |
|---|
| 組織名 | Pharmacoepidemiology and Public Health, Postgraduate Medical School, University;of Surrey, Guildford, Surrey GU2 7DJ. rfarmer@surrey.ac.uk |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/10948026/ |
|---|
