| アブストラクト | OBJECTIVES: To investigate whether the use and timing of prescription of beta blockers in patients with chronic obstructive pulmonary disease (COPD) having a first myocardial infarction was associated with survival and to identify factors related to their use. DESIGN: Population based cohort study in England. SETTING: UK national registry of myocardial infarction (Myocardial Ischaemia National Audit Project (MINAP)) linked to the General Practice Research Database (GPRD), 2003-11. PARTICIPANTS: Patients with COPD with a first myocardial infarction in 1 January 2003 to 31 December 2008 as recorded in MINAP, who had no previous evidence of myocardial infarction in their GPRD or MINAP record. Data were provided by the Cardiovascular Disease Research using Linked Bespoke studies and Electronic Health Records (CALIBER) group at University College London. MAIN OUTCOME MEASURE: Cox proportional hazards ratio for mortality after myocardial infarction in patients with COPD in those prescribed beta blockers or not, corrected for covariates including age, sex, smoking status, drugs, comorbidities, type of myocardial infarction, and severity of infarct. RESULTS: Among 1063 patients with COPD, treatment with beta blockers started during the hospital admission for myocardial infarction was associated with substantial survival benefits (fully adjusted hazard ratio 0.50, 95% confidence interval 0.36 to 0.69; P<0.001; median follow-up time 2.9 years). Patients already taking a beta blocker before their myocardial infarction also had a survival benefit (0.59, 0.44 to 0.79; P<0.001). Similar results were obtained with propensity scores as an alternative method to adjust for differences between those prescribed and not prescribed beta blockers. With follow-up started from date of discharge from hospital, the effect size was slightly attenuated but there was a similar protective effect of treatment with beta blockers started during hospital admission for myocardial infarction (0.64, 0.44 to 0.94; P=0.02). CONCLUSIONS: The use of beta blockers started either at the time of hospital admission for myocardial infarction or before a myocardial infarction is associated with improved survival after myocardial infarction in patients with COPD. REGISTRATION: NCT01335672. |
|---|
| ジャーナル名 | BMJ (Clinical research ed.) |
|---|
| Pubmed追加日 | 2013/11/26 |
|---|
| 投稿者 | Quint, J K; Herrett, E; Bhaskaran, K; Timmis, A; Hemingway, H; Wedzicha, J A; Smeeth, L |
|---|
| 組織名 | Department of Non-Communicable Disease Epidemiology, London School of Hygiene and;Tropical Medicine, London WC1E 7HT, UK. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/24270505/ |
|---|
