| アブストラクト | OBJECTIVE: The objective of the study is to evaluate the effect of gastric banding, gastric bypass and sleeve gastrectomy on medium to long-term diabetes control in obese participants with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: Matched cohort study using primary care electronic health records from the UK Clinical Practice Research Datalink. Obese participants with type 2 diabetes who received bariatric surgery from 2002 to 2014 were compared with matched control participants who did not receive BS. Remission was defined for each year of follow-up as HbA1c <6.5 % and no antidiabetic drugs prescribed. RESULTS: There were 826 obese participants with T2DM who received bariatric surgery including adjustable gastric banding (LAGB) 220; gastric bypass (GBP) 449; or sleeve gastrectomy (SG) 153; with four procedures undefined. Mean HbA1c declined from 8.0 % before BS to 6.5 % in the second postoperative year; proportion with HbA1c <6.5 % (<48 mmol/mol) increased from 17 to 47 %. The proportion of patients in remission was 30 % in the second year, being 20 % for LAGB, 34 % for GBP and 38 % for SG. The adjusted relative rate of remission over the first six postoperative years was 5.97 (4.86 to 7.33, P < 0.001) overall; for LAGB 3.32 (2.27 to 4.86); GBP 7.16 (5.64 to 9.08); and SG 6.82 (5.05 to 9.19). Rates of remission were maintained into the sixth year of follow-up. CONCLUSIONS: Remission of diabetes may continue for up to 6 years after bariatric surgical procedures. Diabetes outcomes are generally more favourable after gastric bypass or sleeve gastrectomy than LAGB. |
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| ジャーナル名 | Obesity surgery |
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| 投稿日 | 2016/2/29 |
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| 投稿者 | Gulliford, Martin C; Booth, Helen Pascale; Reddy, Marcus; Charlton, Judith; Fildes, Alison; Prevost, A Toby; Khan, Omar |
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| 組織名 | King's College London, London, UK.;NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust,;London, UK.;King's College London, London, UK. helen.booth@kcl.ac.uk.;St George's Hospital, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/26922184/ |
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