| アブストラクト | Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Tetrabenazine (TBZ), a vesicular monoamine transporter 2 inhibitor, is commonly used to manage chorea; however, it may exhibit fluctuating plasma levels and elicit frequent adverse events. In this study, we aimed to clarify the effects of TBZ deuteration on its safety profile. We compared the safety profiles of TBZ and deutetrabenazine (DTBZ) in real-world clinical practice using disproportionality analysis and the large-scale pharmacovigilance database, VigiBase-the WHO's global database of adverse drug reactions. Adverse event signals were assessed using the information component (IC). Seriousness was classified according to clinical outcome, and time to onset (TTO) was analyzed for selected events. TBZ showed signals for disorientation, dystonia, and sleep disorders (IC(025) > 0), whereas DTBZ did not. Serious adverse events were reported in 54.7% of TBZ cases and 37.9% of DTBZ cases. The TTO of sleep disorder was also evaluated; however, the number of cases with available TTO information was limited. DTBZ showed fewer adverse event signals and a lower proportion of serious adverse events than TBZ. These findings suggest potential differences in the safety profiles of the two drugs, which may influence tolerability in the treatment of HD. |
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| ジャーナル名 | Biological & pharmaceutical bulletin |
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| Pubmed追加日 | 2026/6/22 |
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| 投稿者 | Kitagawa, Kohei; Nawa, Hideki; Asai, Shota; Iwata, Naohiro; Niimura, Takahiro; Hamano, Hirofumi; Goda, Mitsuhiro; Zamami, Yoshito; Ishizawa, Keisuke |
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| 組織名 | Department of Neuropsychiatry, Okayama Psychiatric Medical Center, 3-16;Shikatahonmachi, Kita-ku, Okayama 700-0915, Japan.;Department of Pharmacy, Faculty of Pharmacy, Shujitsu University, 1-6-1;Nishigawara, Naka-ku, Okayama 703-8516, Japan.;Department of Pharmacy, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku,;Okayama 700-8558, Japan.;Department of Clinical Pharmacology and Therapeutics, Tokushima University;Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan.;Department of Clinical Pharmacology and Therapeutics, Graduate School of;Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku,;Hiroshima 734-8553, Japan.;Clinical Research Center for Developmental Therapeutics, Tokushima University;Hospital, Tokushima 770-0042, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42324134/ |
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