| アブストラクト | Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has not been fully investigated. We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively identify patients who had received CPT-11 on their first admission with and without TJ-14. Patients who did receive TJ-14 (N = 7092) received CPT-11 more often and in larger doses than those who did not receive TJ-14 (N = 82,019). The incidence rate ratio of CPT-11 administration was 1.34 for frequency (95% confidence interval [CI], 1.31(-)1.38; p < 0.001), and 1.16 for total dose (95% CI, 1.14(-)1.19; p < 0.001) according to stabilized inverse probability treatment weighting using propensity scores. Instrumental variable analysis showed similar trends. In-hospital mortality was significantly lower in patients who received TJ-14 than in those who did not. Odds ratios of in-hospital death in patients receiving TJ-14 was 0.81 (95% CI, 0.71(-)0.93; p = 0.002) according to stabilized inverse probability treatment weighting using propensity scores and 0.42 (95% CI, 0.22(-)0.81; p = 0.009) according to instrumental variable analysis. Our findings indicate that TJ-14 improve the tolerability of CPT-11. |
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| 投稿者 | Urushiyama, Hirokazu; Jo, Taisuke; Yasunaga, Hideo; Michihata, Nobuaki; Yamana, Hayato; Matsui, Hiroki; Hasegawa, Wakae; Hiraishi, Yoshihisa; Mitani, Akihisa; Fushimi, Kiyohide; Nagase, Takahide; Yamauchi, Yasuhiro |
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| 組織名 | Department of Respiratory Medicine, Graduate School of Medicine, The University;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. hiro-urushi@umin.ac.jp.;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. jo-taisuke@umin.ac.jp.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.;jo-taisuke@umin.ac.jp.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.;yasunagah-tky@umin.ac.jp.;michihata-tky@umin.org.;yamana-tky@umin.ac.jp.;ptmatsui-tky@umin.ac.jp.;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.;wakaetnk0703@yahoo.co.jp.;blueeyedsoul1980@gmail.com.;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. mitania-tky@umin.ac.jp.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.;kfushimi.hci@tmd.ac.jp.;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. takahide-tky@umin.ac.jp.;of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yas-kkr@umin.ac.jp. |
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