| アブストラクト | OBJECTIVES: To evaluate the effectiveness and safety of stress ulcer prophylaxis (SUP) with proton-pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs) in preventing gastrointestinal bleeding (GIB) in patients with severe burns, using a Japanese nationwide inpatient database. DESIGN: Retrospective cohort study. SETTING: Acute-care hospitals participating in the Diagnosis Procedure Combination inpatient database between 2010 and 2022. PATIENTS: A total of 5623 patients with a burn index >/= 15 who were hospitalized between July 2010 and March 2022. INTERVENTIONS: Pharmacological SUP with vs. without PPIs/H2RAs. MEASUREMENTS AND MAIN RESULTS: Among the 5623 eligible patients with burns, 2031 (36.1%) received PPIs or H2RAs for at least 7 consecutive days, whereas 3592 (63.9%) either did not receive PPIs or H2RAs or received them for fewer than 7 consecutive days. After propensity score overlap-weighting adjustment, there were no statistically significant differences between the two groups in the risk of GIB [risk difference (RD) 0.06%, 95% confidence interval (CI) -0.73-0.85], Clostridioides difficile infection (CDI) (RD 0.86%, 95% CI -0.55-2.27), or hospital-acquired pneumonia (HAP) (RD 0.36%, 95% CI -1.26-1.98). CONCLUSIONS: In patients with severe burns, PPIs/H2RAs were not associated with a reduction in GIB, or an increase in CDI or HAP. Therefore, routine SUP may not be essential for such patients. |
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| ジャーナル名 | Burns : journal of the International Society for Burn Injuries |
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| Pubmed追加日 | 2026/11/2 |
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| 投稿者 | Shigeno, Ayami; Aso, Shotaro; Osuka, Akinori; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo |
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| 組織名 | Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan. Electronic address:;a-shigeno@g.ecc.u-tokyo.ac.jp.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Department of Trauma, Critical Care Medicine and Burn Center Japan Community;Health Care Organization Chukyo Hospital, Aichi, Japan.;Health, The University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Institute of Science Tokyo Graduate;School, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42971008/ |
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