| アブストラクト | OBJECTIVE: Short-term recurrence is common in patients with peritonsillar cellulitis and abscesses, leading to socioeconomic problems. Early switching from intravenous to oral antibiotics is feasible for treating certain diseases. However, reports on early switching and total antibiotic administration duration in peritonsillar cellulitis and abscesses are limited. This study aimed to determine the appropriate antibiotic therapy duration and examine the impact of early oral switch therapy on peritonsillar cellulitis and abscesses. METHODS: We retrospectively identified 98,394 patients who received antibiotic therapy during hospitalization for peritonsillar cellulitis and abscesses between July 1, 2010, and December 31, 2019, using the Japanese Diagnosis Procedure Combination database. RESULTS: Propensity score matching analysis revealed no significant between-group difference in the rehospitalization rate (early oral switch therapy and long intravenous therapy: 1.7 % [198 of 11,621] vs. 2.0 % [234 of 11,621], odds ratio [OR] 0.84, 95 % confidence interval [CI] 0.70-1.02). A long total duration of antibiotic therapy (reference: 1-9 days) was associated with a low risk of rehospitalization (10-14 days: OR 0.86, 95 % CI 0.78-0.95; 15+ days: OR 0.51, 95 % CI 0.38-0.66). CONCLUSION: Early oral switch therapy may be a viable option for treating patients with peritonsillar cellulitis and abscesses in good condition who can tolerate oral intake. No less than 10 days of antibiotic therapy is desirable. |
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| ジャーナル名 | Auris, nasus, larynx |
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| 投稿日 | 2024/3/24 |
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| 投稿者 | Kondo, Keisuke; Inoue, Norihiko; Honda, Keiji; Fushimi, Kiyohide |
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| 組織名 | Department of Health Policy and Informatics, Graduate School of Medical and;Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of;Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.;Clinical Data Management and Research, Clinical Research Center, National;Hospital Organization Headquarters, Tokyo, Japan.;Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo,;Japan.;Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic;address: kfushimi.hci@tmd.ac.jp. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38520976/ |
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