| アブストラクト | AIMS: This study aimed to provide a comprehensive view of cardiovascular adverse events (AEs) associated with venlafaxine (VEN) therapy. METHODS: Cardiovascular AE reports for patients receiving VEN therapy were retrieved from January 2004 to December 2023 from the FDA Adverse Event Reporting System database. Effects of age, sex and daily VEN dose on the occurrence of different types of cardiovascular AEs and the influence of demographics, VEN dose, comorbidity and co-medication on death in patients with cardiovascular AEs were analysed by multivariate logistic regression analysis. RESULTS: The study included 16 110 AE reports following VEN treatment (median age: 51 years, females: 69.78%, median VEN daily dose: 100 mg/day). VEN daily dose was associated with increased risks of cardiac arrhythmias, embolic and thrombotic events, torsade de pointes/QT prolongation, ischaemic heart disease, cardiac failure, cardiomyopathy and overall cardiovascular events. The elderly (>/= 75 years), male sex, comorbidity (infections and infestations, cardiac disorders, nervous system disorders) and co-medication (quetiapine and clozapine) were related to death following VEN-associated cardiovascular AEs; however, the risk of cardiovascular death did not increase with regular VEN doses. CONCLUSIONS: Our study confirmed the association of cardiovascular AEs with VEN therapy and revealed the influencing factors for the risk of VEN-related cardiovascular AEs and death due to these events. Based on the obtained evidence, the cardiovascular health of late-elderly patients with complex comorbidity and polytherapy should be closely monitored when they receive VEN therapy. As an exploratory study, prospective studies are needed to validate our findings in the future. |
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| ジャーナル名 | British journal of clinical pharmacology |
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| Pubmed追加日 | 2024/10/30 |
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| 投稿者 | Wang, Zhanzhang; Lu, Haoyang; Li, Yuandan; Huang, Shanqing; Zhang, Ming; Wen, Yuguan; Shang, Dewei |
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| 組織名 | The Affiliated Brain Hospital, Guangzhou Medical University, 36 Mingxin Road,;Guangzhou, China.;Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the;Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39471573/ |
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