Effects of edaravone on early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator.
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アブストラクト BACKGROUND:We investigated whether edaravone could improve early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator (rtPA).METHODS:We conducted a retrospective cohort study using the Japanese Diagnosis Procedure Combination database. We identified patients admitted with a primary diagnosis of ischemic stroke from 1 July 2010 to 31 March 2012 and treated with rtPA on the same day of stroke onset or the following day. Thereafter, we selected those who received edaravone on the same day of rtPA administration (edaravone group), and those who received rtPA without edaravone (control group). The primary outcomes were modified Rankin Scale (mRS) scores at discharge. One-to-one propensity-score matching was performed between the edaravone and control groups. An ordinal logistic regression analysis for mRS scores at discharge was performed with adjustment for possible variables as well as clustering of patients within hospitals using a generalized estimating equation.RESULTS:We identified 6336 eligible patients for inclusion in the edaravone group (n=5979; 94%) and the control group (n=357; 6%) as the total population. In 356 pairs of the propensity-matched population, the ordinal logistic regression analysis showed that edaravone was significantly associated with lower mRS scores of patients at discharge (adjusted odds ratio: 0.74; 95% confidence interval: 0.57-0.96).CONCLUSIONS:Edaravone may improve early outcomes in acute ischemic stroke patients treated with rtPA.ジャーナル名 Journal of the neurological sciences 投稿日 2014/8/3 投稿者 Wada, Tomoki; Yasunaga, Hideo; Inokuchi, Ryota; Horiguchi, Hiromasa; Fushimi, Kiyohide; Matsubara, Takehiro; Nakajima, Susumu; Yahagi, Naoki 組織名 Department of Emergency and Critical Care Medicine, The University of Tokyo;Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address:;wadat-eme@h.u-tokyo.ac.jp.;Department of Clinical Epidemiology and Health Economics, The University of;Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address:;yasunagah-tky@umin.ac.jp.;inokuchir-icu@h.u-tokyo.ac.jp.;Department of Clinical Data Management and Research, Clinical Research Center,;National Hospital Organization Headquarters, 2-5-21 Higashigaoka, Meguro-ku,;Tokyo 152-8621, Japan. Electronic address: hiromasa-horiguchi@nho.hosp.go.jp.;Department of Health Care Informatics, Tokyo Medical and Dental University,;1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.;matsubarat-ort@h.u-tokyo.ac.jp.;nakajimas-ort@h.u-tokyo.ac.jp.;yahagin-eme@h.u-tokyo.ac.jp. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/25085762/ -
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