| アブストラクト | OBJECTIVES: Acute pancreatitis (AP) guidelines for adult patients do not recommend routine prophylactic use of antibiotics because of no clinical merit on mortality, infectious complications, or length of stay. Although the mortality of pediatric AP is low, no studies have explored the rationale for antibiotic use in pediatric patients. The aim of this study was to evaluate the effects of early prophylactic antibiotics on length of stay and total costs in pediatric patients. METHODS: Using the Japanese Diagnosis Procedure Combination database from 2010 to 2017, we used the stabilized inverse probability of treatment weighting method using propensity scores to balance the background characteristics in the antibiotics group and the control group, and compared length of stay and total costs between the groups. RESULTS: We found significant differences between the antibiotics group (n = 652) and the control group (n = 467) in length of stay (11 days vs 9 days; percent difference, 15.4%; 95% confidence interval, 5.0%-26.8%) and total costs (US $4085 vs US $3648; percent difference, 19.8%; 95% confidence interval, 8.0%-32.9%). CONCLUSIONS: Prophylactic antibiotics were associated with longer length of stay and higher total costs. Our results do not support routine use of prophylactic antibiotics in pediatric AP populations. |
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| ジャーナル名 | Pancreas |
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| 投稿日 | 2020/10/31 |
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| 投稿者 | Ikeda Kurakawa, Kayo; Okada, Akira; Jo, Taisuke; Ono, Sachiko; Bessho, Kazuhiko; Michihata, Nobuaki; Matsui, Hiroki; Yamaguchi, Satoko; Fushimi, Kiyohide; Kadowaki, Takashi; Yasunaga, Hideo |
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| 組織名 | From the Department of Prevention of Diabetes and Lifestyle-Related Diseases.;Department of Health Services Research.;Department of Eat-loss Medicine, Graduate School of Medicine, The University of;Tokyo, Tokyo.;Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine.;Toranomon Hospital, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33122520/ |
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