| アブストラクト | PURPOSE: Some studies have suggested a potential risk of heart failure in patients with Parkinson's disease receiving dopamine (DA) agonists. However, the results are conflicting. We used VigiBase(R), the World Health Organization (WHO) Global Individual Case Safety Reports (ICSRs) database, to investigate a potential signal strengthening of heart failure with DA agonists in Parkinsonian patients older than 45 years. METHODS: A case/non-case (disproportionality) analysis was performed in Vigibase(R) using ICSRs registered between 1978 and May 2016. The signal of disproportionality was calculated using reporting odds ratios (ROR). In our study, 154 ICSRs of heart failure occurring in 154 Parkinsonian patients (mean age 69.6 years, 51 % women) treated with DA agonists were included. RESULTS AND CONCLUSION: There was a significant signal between occurrence of heart failure and exposure to pergolide or cabergoline in particular and ergot derivatives in general. In contrast, none signal was found for rotigotine, pramipexole, apomorphine, or ropinirole in particular and non-ergot derivatives in general. The present study underlines the importance to prescribe as DA agonists in Parkinsonian patients only non-ergot derivatives, excluding ergot drugs. |
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| 組織名 | Laboratoire de Pharmacologie Medicale et Clinique de la Faculte de Medecine et du;Centre Hospitalier Universitaire de Toulouse, Toulouse, France.;Centre Midi-Pyrenees de PharmacoVigilance, de Pharmacoepidemiologie et;d'Informations sur le Medicament, Pharmacopole Midi-Pyrenees, Centre Hospitalier;Universitaire de Toulouse, Toulouse, France.;INSERM UMR 1027, Faculte de Medecine, Universite de Toulouse, Toulouse, France.;CIC INSERM 1436, Universite et Centre Hospitalier Universitaire de Toulouse,;Toulouse, France.;NeuroToul Centre of Excellence in Neurodegeneration, Universite et Centre;Hospitalier Universitaire deToulouse, Toulouse, France.;INSERM UMR 825, Universite de Toulouse, Toulouse, France.;jean-louis.montastruc@univ-tlse3.fr.;Universitaire de Toulouse, Toulouse, France. jean-louis.montastruc@univ-tlse3.fr.;Toulouse, France. jean-louis.montastruc@univ-tlse3.fr. |
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