| アブストラクト | BACKGROUND: Polypharmacy is common in headache medicine. This project uses DrugBank and Food and Drug Administration's (FDA) Adverse Event Reporting System (FAERS) to determine the likelihood of a theoretical and empirically reported interaction between a given number of headache abortive and preventive medications. METHODS: All headache medications referenced in "The American Headache Society Position Statement on Integrating New Migraine Treatments into Clinical Practice" and Szperka's "Migraine care in the era of COVID-19: clinical pearls and plea to insurers" were included. All possible combinations of up to three abortives and preventatives were screened for drug-drug interactions through searches in DrugBank and FAERS. If at least one drug-drug interaction was listed, then it was included in our analysis. The percentage of combinations containing an interaction was then compared across the two databases. RESULTS: Of the 38 abortives and 23 preventives included, once more than 3 drugs are used in any combination, a drug-drug interaction was >99% likely, per DrugBank. However, per FAERS, the reported interaction was 39% to 60% likely once 3 or 4 drugs are used in any combination. In FAERS, the likelihood of interaction rised most dramatically once 3 or more drugs are used. CONCLUSIONS: Theoretical interactions, based on DrugBank, maybe overstated when compared to actual observed interactions in FAERS. Future direction is needed delving into the types of interactions recorded in each database. |
|---|
| ジャーナル名 | Journal of oral & facial pain and headache |
|---|
| Pubmed追加日 | 2025/12/24 |
|---|
| 投稿者 | Kaytser, Victor; Hakkinen, Ian; Dave, Jay; Zhang, Pengfei |
|---|
| 組織名 | UT Southwestern Medical Center, Dallas, TX 75390, USA.;Evergreen Health, Seattle, WA 98272, USA.;Mount Sinai Hospital, New York, NY 10029, USA.;Harvard Medical School, Boston, MA 02218, USA.;Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02218,;USA. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41436113/ |
|---|
