| アブストラクト | Background: Norovirus is the leading cause of community-acquired and nosocomial acute gastroenteritis. Routine testing for norovirus is seldom undertaken, and diagnosis is mainly based on presenting symptoms. This makes understanding the burden of medically attended norovirus-attributable gastroenteritis (MA-NGE) and targeting care and prevention strategies challenging. Methods: We used linked population-based healthcare datasets (Clinical Practice Research Datalink General Practice OnLine Database linked with Hospital Episode Statistics Admitted Patient Care) to model the incidence of MA-NGE associated with primary care consultations or hospitalizations according to age groups in England in the period July 2007-June 2013. Results: Mean annual incidence rates of MA-NGE were 4.9/1000 person-years and 0.7/1000 person-years for episodes involving primary care or hospitalizations, respectively. Incidence rates were highest in children aged <5 years: 34.0 consultations/1000 person-years and 3.3 hospitalizations/1000 person-years. Medically attended norovirus-attributable gastroenteritis hospitalization rates were second highest in adults aged >65 years (1.7/1000 person-years). Conclusions: In this particular study, the burden of MA-NGE estimated from healthcare datasets was higher than previously estimated in small cohort studies in England. Routinely collected primary care and hospitalization datasets are useful resources to estimate and monitor the burden of MA-NGE in a population over time. |
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| ジャーナル名 | The Journal of infectious diseases |
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| 投稿日 | 2017/9/30 |
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| 投稿者 | Verstraeten, Thomas; Cattaert, Tom; Harris, John; Lopman, Ben; Tam, Clarence C; Ferreira, Germano |
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| 組織名 | P95 Pharmacovigilance and Epidemiology, Heverlee, Belgium.;National Institute for Health Research Health Protection Research Unit in;Gastrointestinal Infections, University of Liverpool.;Rollins School of Public Health, Emory University, Atlanta, Georgia.;Department of Infectious Disease Epidemiology, London School of Hygiene &;Tropical Medicine, United Kingdom.;Saw Swee Hock School of Public Health, National University of Singapore. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28961927/ |
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