| アブストラクト | OBJECTIVE: This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon-like peptide-1 receptor agonists (GLP-1RAs) using the US FDA Adverse Event Reporting System (FAERS). Emphasis was placed on emerging safety concerns in context-specific use. METHODS: A retrospective analysis of FAERS reports between 2012 and 2025 was conducted. Five commonly prescribed FDA-approved GLP-1RAs were included. Disproportionality analyses were applied to detect AE signals. Subgroup analyses evaluated associations by indication, GLP-1RAs compared to other drugs, and AEs specific to individual GLP-1RAs. RESULTS: From over 18 million FAERS reports, 137,451 involved GLP-1RAs. The most frequent AEs were gastrointestinal, nutritional and metabolic, and psychiatric disorders, occurring at higher rates compared to other drugs. In diabetes use, GLP-1RAs were associated with retinopathy, hearing loss, and cataracts. In contrast, when prescribed for weight management/obesity, nutritional, metabolic, and psychiatric AEs predominated. We also developed an open-access portal for AE exploration, available at http: //glp1.tanlab.org. CONCLUSIONS: GLP-1RAs are linked to a broad range of AEs across indications. These findings stress the need for careful clinical monitoring and long-term safety evaluation. This study also illustrates how real-world evidence can inform safety communications, as well as hypothesis generation for research on next-generation GLP-1RAs. |
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| ジャーナル名 | Obesity (Silver Spring, Md.) |
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| Pubmed追加日 | 2026/3/9 |
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| 投稿者 | Stone, David; Playdon, Mary; Hursting, Stephen D; Tan, Aik Choon |
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| 組織名 | Departments of Oncological Sciences and Biomedical Informatics, University of;Utah, Salt Lake City, Utah, USA.;Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.;Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake;City, Utah, USA.;Department of Nutrition, University of North Carolina at Chapel Hill, Chapel;Hill, North Carolina, USA.;Nutrition Research Institute, University of Carolina at Chapel Hill, Kannapolis,;North Carolina, USA.;Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel;Hill, Chapel Hill, North Carolina, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41797511/ |
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