| アブストラクト | BACKGROUND: New anticancer therapies have improved patient outcomes but associated dermatologic adverse events (AEs) may cause morbidity and treatment discontinuation. A comprehensive estimation of associations between cancer drugs and skin AEs is lacking. METHODS: This study utilized the Food and Drug Administartion (FDA)'s Adverse Event Reporting System database (January 2013-September 2022), with 3,399,830 reports involving 3084 drugs and 16,348 AEs. A nearest neighbor matching model was employed to select 10 controls for each case report, utilizing the cosine similarity of demographic and AE severity factors to minimize false positives/negatives. RESULTS: There were 10,698 unique anticancer drugs (n = 212) to skin AE (n = 873) pairs, of which 676 had significant reporting odds ratios (ROR) > 1, comprising 113 drugs and 144 AEs. The minimum ROR was 1.25, and 50% of associations displayed a ROR >10. The most common were rash (51 agents) and dry skin (28 drugs). Methotrexate induced the most distinct AEs (34), then mechlorethamine (33), and vemurafenib (24). Targeted therapies accounted for 49% of pairs, cytotoxic chemotherapies for 35.9%, and immunotherapies for 11%. CONCLUSIONS: A total of 113 anticancer drugs were identified as significantly associated with skin AEs, most frequently rash and dry skin. Data are likely under-reported but enable quick postmarketing identification of skin toxicity signals. |
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| ジャーナル名 | Journal of the American Academy of Dermatology |
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| 投稿日 | 2024/7/23 |
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| 投稿者 | Salah, Samir; Kerob, Delphine; Pages Laurent, Cecile; Lacouture, Mario; Sibaud, Vincent |
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| 組織名 | La Roche-Posay Laboratoire Dermatologique, Levallois Perret, France. Electronic;address: samir.salah@loreal.com.;La Roche-Posay Laboratoire Dermatologique, Levallois Perret, France.;Departments of Oncodermatology and Clinical Research, Institut Universitaire du;Cancer, Toulouse Oncopole, France.;Department of Medicine, New York University Langone, New York, New York. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39038557/ |
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