| アブストラクト | AIMS: Contemporary data describing type 2 diabetes prevalence, incidence and mortality are limited. We aimed to (1) estimate annual incidence and prevalence rates of type 2 diabetes in the UK between 2004 and 2014, (2) examine relationships between observed rates with age, gender, socio-economic status and geographic region, and (3) assess how temporal changes in incidence and all-cause mortality rates influence changes in prevalence. METHODS: Type 2 diabetes patients aged >/=16 years between January 2004 and December 2014 were identified using the Clinical Practice Research Datalink (CPRD). Up to 5 individuals without diabetes were matched to diabetes patients based on age, gender and the general practice. Annual incidence, prevalence and mortality rates were calculated per 10 000 person-years at risk (95% CI). Survival models compared mortality rates in patients with and without type 2 diabetes. RESULTS: Prevalence rates of type 2 diabetes increased from 3.21% (3.19; 3.22) in 2004 to 5.26% (5.24; 5.29) in 2014. Incidence rates remained stable, overall, throughout the study period. Higher incidence and prevalence rates were related to male gender and deprivation. Individuals with type 2 diabetes were associated with higher risk of mortality (Hazard ratio 1.26 [1.20; 1.32]). Mortality rates declined in patients with and without diabetes throughout the study period. The incidence and prevalence of type 2 diabetes in patients aged 16 to 34 years increased over time. CONCLUSIONS: The rising prevalence of type 2 diabetes in the UK over the last decade is probably explained by patients living longer rather than by increasing incidence of type 2 diabetes. |
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| 組織名 | Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and;Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health,;University of Manchester, Manchester Academic Health Sciences Centre (MAHSC),;Manchester, UK.;Department of Pharmaceutics, Faculty of Pharmacy, University of Tripoli, Tripoli,;Libya.;Division of Psychology and Mental Health, School of Health Sciences, Faculty of;Biology, Medicine and Health, University of Manchester, Manchester, UK.;Division of Diabetes, Endocrinology and Gastroenterology, School of Medical;Sciences, Faculty of Biology, Medicine and Health, University of Manchester,;Manchester Diabetes Centre, Central Manchester University Hospitals NHS;Foundation Trust, Manchester Academic Health Science Centre (MAHSC), Manchester,;UK.;Centre for Biostatistics, Division of Population Health, Health Services Research;& Primary Care, School of Health Sciences, Faculty of Biology, Medicine and;Health, University of Manchester, Manchester Academic Health Science Centre;(MAHSC), Manchester, UK. |
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