| アブストラクト | INTRODUCTION: Arrhythmias resulting from newer antiseizure medications (ASMs) may significantly impact the safety and quality of life of patients with epilepsy. This study investigated the potential association between new first-line or second-line ASMs and arrhythmias. METHODS: Pharmacovigilance analysis was conducted using data from the Food and Drug Administration Adverse Event Reporting System (FAERS) from 2004 to 2023. A disproportionality analysis was performed to compare newer ASMs with other drugs, using carbamazepine and valproate as positive controls. Newer ASMs were categorized into sodium channel (SCN) main mechanism, SCN possible mechanism, and non-SCN group. The bioinformatics analysis involved retrieving therapeutic gene targets for ASMs from the DrugBank and OMIM databases, as well as identifying arrhythmia disease targets from the GeneCards database. Additionally, enrichment analysis of gene ontology functions and KEGG pathways was conducted. RESULTS: A total of 3,457 cases of arrhythmias associated with newer ASMs were identified in the FAERS database. Disproportionality analysis indicates that brivaracetam (IC025 = 0.08), zonisamide (IC025 = 0.13), eslicarbazepine (IC025 = 0.39), and lacosamide (IC025 = 0.84) exhibited a positive signal for arrhythmias, with signals predominantly observed in the SCN main mechanism group. Furthermore, bioinformatics analysis revealed the involvement of adrenergic signaling in cardiac myocytes, as well as the participation of sodium channel genes in ASM-induced arrhythmias. CONCLUSION: Our findings suggest a potential association between SCN-ASMs and arrhythmias, highlighting the importance of monitoring and evaluating the safety profiles of newer ASMs in clinical practice. Further research is necessary to elucidate the underlying mechanisms and inform patient care strategies. |
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| 組織名 | Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xinquan Rd.;Gulou District, Fuzhou, Fujian 350001, China; School of Pharmacy, Fujian Medical;University, Fuzhou, Fujian, China. Electronic address: zhoujianxing@fjmu.edu.cn.;Department of Pharmacy, Zhongshan Hospital (Xiamen), Fudan University, Xiamen,;Fujian, China.;State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty;of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China.;Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.;University, Fuzhou, Fujian, China. Electronic address: wuxuemei@fjmu.edu.cn. |
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