| アブストラクト | INTRODUCTION: Yawning is a normal, stereotyped physiological event in humans and animal kingdom. When excessive (>3 per 15 minutes), it is termed as pathological yawning (PY). PY could be due to many causes but more commonly associated with side-effect of drugs, notably involving those used in psychopharmacology. Though there are isolated case reports and case-series, there are no large-scale reports of PY. This work attempted to address this lacuna. MATERIAL AND METHODS: The current work attempted to identify characteristics of PY as collated from adverse drug effect databases of Australia (Database of Adverse Event Notifications), Canada (Canada Vigilance Adverse Reaction Online Database) and the United States of America (FDA Adverse Event Reporting System - FAERS). These databases collect and provide public access to reports of adverse events related to drugs and therapeutic goods. They act as a prime pharmacovigilance tool as well as a first-line resource for healthcare professionals, researchers, and the public to monitor the safety of these products and make informed decisions. In the first week of June 2023, open access, unrestricted adverse effect of drug databases were explored, using the word "YAWNING" as the only search term for the side effect of any drug without any restrictions. The collected details of PY cases with their gender, age, reason for drug use, other concomitant complaints as well as the nature of adverse event(s) and its treatment requirements were assessed. Descriptive statistics were used. RESULT: Of the 2655 instances in USA database, 398(15%) had more than 1 suspect drug and in total 578 medications involved. The most commonly involved drugs were apomorphine, sertraline, fluoxetine and paroxetine. In all 341(12.8%) cases reported of YAWN alone or with one another sleep disorder, the most common off ending drug were fluoxetine hydrochloride. DISCUSSION AND CONCLUSION: The neural mechanism and physiology of yawning are explained. This study stresses that a health care professional, particularly mental health professionals and neurologists, should be aware of the importance of PY to deliver the best for the patients under their care. (Neuropsychopharmacol Hung 2023; 25(4): 194-205) |
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| ジャーナル名 | Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology |
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| 投稿日 | 2024/1/4 |
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| 投稿者 | Mohandoss, Anusa Arunachalam; Thavarajah, Rooban |
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| 組織名 | Department of Psychiatry, Shri Sathya Sai Medical College and Research Institute,;Affi liated to Shri Balaji Vidyapeeth (Deemed to be University) , SBV Chennai;Campus, Shri Sathya Sai Nagar, Ammapettai, Chengelpet, Tamil Nadu, India.;Marundeeswara Oral Pathology Services and Analytics, Chennai, India.;Department of Oral Pathology, Ragas Dental College and Hospital, Chennai, India,;Affiliated to the Tamil Nadu Dr. MGR Medical University, Chennai |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38170730/ |
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