| アブストラクト | OBJECTIVE: Automated analysis of vaccine postmarketing surveillance narrative reports is important to understand the progression of rare but severe vaccine adverse events (AEs). This study implemented and evaluated state-of-the-art deep learning algorithms for named entity recognition to extract nervous system disorder-related events from vaccine safety reports. MATERIALS AND METHODS: We collected Guillain-Barre syndrome (GBS) related influenza vaccine safety reports from the Vaccine Adverse Event Reporting System (VAERS) from 1990 to 2016. VAERS reports were selected and manually annotated with major entities related to nervous system disorders, including, investigation, nervous_AE, other_AE, procedure, social_circumstance, and temporal_expression. A variety of conventional machine learning and deep learning algorithms were then evaluated for the extraction of the above entities. We further pretrained domain-specific BERT (Bidirectional Encoder Representations from Transformers) using VAERS reports (VAERS BERT) and compared its performance with existing models. RESULTS AND CONCLUSIONS: Ninety-one VAERS reports were annotated, resulting in 2512 entities. The corpus was made publicly available to promote community efforts on vaccine AEs identification. Deep learning-based methods (eg, bi-long short-term memory and BERT models) outperformed conventional machine learning-based methods (ie, conditional random fields with extensive features). The BioBERT large model achieved the highest exact match F-1 scores on nervous_AE, procedure, social_circumstance, and temporal_expression; while VAERS BERT large models achieved the highest exact match F-1 scores on investigation and other_AE. An ensemble of these 2 models achieved the highest exact match microaveraged F-1 score at 0.6802 and the second highest lenient match microaveraged F-1 score at 0.8078 among peer models. |
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| 投稿日 | 2021/3/2 |
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| 投稿者 | Du, Jingcheng; Xiang, Yang; Sankaranarayanapillai, Madhuri; Zhang, Meng; Wang, Jingqi; Si, Yuqi; Pham, Huy Anh; Xu, Hua; Chen, Yong; Tao, Cui |
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| ジャーナル名 | Journal of the American Medical Informatics Association : JAMIA |
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| 組織名 | School of Biomedical Informatics, The University of Texas Health Science Center;at Houston, Houston, Texas, USA.;Perelman School of Medicine, University of Pennsylvania, Philadelphia,;Pennsylvania, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/33647938/ |
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