| アブストラクト | BACKGROUND AND AIM: Adverse drug reactions are one of the contributors to increased hospital admission and length of hospital stay. Among the various antidiabetic agents prescribed, dipeptidyl peptidase-4 (DPP-4) inhibitors have gained wide recognition and shown more persistence than other novel hypoglycemic agents. We performed a scoping review to identify the risk factors contributing to the adverse drug reactions with DPP-4 inhibitors. METHODOLOGY: We followed Preferred Reporting Items for Scoping Review (PRISMA-ScR) Guidelines for reporting the findings. Data sources such as PubMed/MEDLINE, Scopus, Embase, and Cochrane were assessed. We included studies that reported the risk factors contributing to the DPP-4 inhibitor-associated adverse drug reactions. The Joanna Briggs Institute (JBI) critical appraisal checklist was used to assess the methodological quality of the studies. RESULTS: Of the 6406 studies retrieved, 11 studies met our inclusion criteria. Of these 11 studies, seven were post-marketing surveillance studies, one nested case-control study, one comparator cohort study, one food and drug administration (FDA) adverse event reporting system (FAERS)-based observational study, and one questionnaire-based cross-sectional survey study. A total of eight factors were identified that contributed to the DPP-4 inhibitor-associated adverse drug reactions. CONCLUSION: The included studies suggested age >65 years, females, grade 4 and 5 renal impairment, concomitant drugs, disease and drug therapy duration, liver disease, non-smokers, and non-hypertension as risk factors. Further studies should be conducted to provide insight into these risk factors so that the appropriate use of DPP-4 inhibitors in the diabetic population can be encouraged to improve the health-related quality of life. PROSPERO REGISTRATION: CRD42022308764. |
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| ジャーナル名 | Diabetes & metabolic syndrome |
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| Pubmed追加日 | 2023/6/18 |
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| 投稿者 | Reghunath, Swetha R; Rashid, Muhammed; Chandran, Viji Pulikkel; Thunga, Girish; Shivashankar, K N; Acharya, Leelavathi D |
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| 組織名 | Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences,;Manipal Academy of Higher Education, Manipal, Udupi District, Karnataka, 576 104,;India. Electronic address: swetha.reghunath@learner.manipal.edu.;India. Electronic address: muhammed.rashid@learner.manipal.edu.;India. Electronic address: viji.chandran@learner.manipal.edu.;India. Electronic address: girish.thunga@manipal.edu.;Department of General Medicine, Kasturba Medical College, Manipal Academy of;Higher Education, Manipal, Udupi District, Karnataka, 576 104, India. Electronic;address: shi.sha@manipal.edu.;India. Electronic address: leela.da@manipal.edu. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37329838/ |
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