| アブストラクト | Adverse drug reactions (ADRs) pose a global public health threat, substantially contributing to death. Due to the relative paucity of clinical evidence regarding fatal ADRs, this study was performed to characterize the epidemiology of fatal ADRs in Korea. This was a retrospective, cross-sectional analysis of ADR cases reported to the Korea Adverse Event Reporting System from 2010 to 2019. All ADRs were coded using the World Health Organization-Adverse Reaction Terminology system and classified as either fatal or non-fatal events. Logistic regression was performed to identify factors associated with fatal events. Among 289,756 ADR records, 629 fatal events (0.2%) occurred. The most common causative agent of fatal ADRs was antibacterials (20.3%), followed by antimycobacterials (5.4%), analgesics (4.0%), and contrast media (1.9%). Among antimicrobials, vancomycin was most frequently implicated without significantly increasing the risk of fatal events. The risk for fatal ADRs was significantly increased with male sex; advanced age; polypharmacy; piperacillin/beta-lactamase inhibitor; cefotetan; ceftriaxone; combination antimycobacterial therapy consisting of rifampicin, isoniazid, pyrazinamide, and ethambutol; morphine; and iopromide (reporting odds ratio > 1, p < 0.05 for all). Although fatal ADRs are uncommon (<1%) in Korea, they are primarily caused by commonly used medications including antibiotics, analgesics, and contrast media. |
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| ジャーナル名 | Journal of personalized medicine |
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| Pubmed追加日 | 2022/1/22 |
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| 投稿者 | Jo, Hyeong-Geun; Jeong, Kyeoul; Ryu, Ji-Young; Park, Soyun; Choi, Yun-Seok; Kwack, Won-Gun; Choi, Yeo-Jin; Chung, Eun-Kyoung |
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| 組織名 | Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447,;Korea.;Division of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University;Hospital, Seoul 02447, Korea.;Department of Clinical Pharmacy, Graduate School of Clinical Pharmacy, CHA;University, Seongnam 13488, Korea.;Department of Pharmacy, Kyung Hee University Hospital at Gangdong, Seoul 05278,;Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul;02447, Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35055318/ |
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