| アブストラクト | PURPOSE: Fluindione is an oral vitamin K antagonist (indanedione derivative) exclusively marketed in France and Luxembourg, known to have immuno-allergic adverse effects such as hepatitis, fever or interstitial nephritis. A few cases of drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported with fluindione. The aim of the present study was to investigate fluindione-induced DRESS cases reported in France and to describe their characteristics. METHODS: We searched for potential cases of DRESS with fluindione reported in the French pharmacovigilance database since 2000. RESULTS: Thirty-six cases of DRESS were included and concerned 17 women and 19 men. The mean age was 65 years (median: 68 years, range: 28-95 years). Kidneys and liver were the most frequent organs involved. Thirty-five cases were serious. In 5 cases, the effect was life-threatening. Most of the patients recovered. Fluindione was the only medicine suspected in 26 cases. Skin patch tests, performed in 10 cases, were positive with fluindione in 9 cases. CONCLUSIONS: Fluindione is not known to be a frequent cause of DRESS. However, the number of reports found is probably underestimated. The seriousness of DRESS, as all immuno-allergic adverse effects, contraindicates fluindione reintroduction. Coumarinic derivatives are the alternatives in patients who need oral anticoagulant treatment. |
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| ジャーナル名 | European journal of clinical pharmacology |
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| 投稿日 | 2011/7/28 |
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| 投稿者 | Daveluy, Amelie; Milpied, Brigitte; Barbaud, Annick; Lebrun-Vignes, Benedicte; Gouraud, Aurore; Laroche, Marie-Laure; Ciobanu, Ecaterina; Begaud, Bernard; Moore, Nicholas; Miremont-Salame, Ghada; Haramburu, Francoise |
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| 組織名 | Universite de Bordeaux, U657, 33000, Bordeaux, France.;amelie.daveluy@u-bordeaux2.fr |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/21792562/ |
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