| アブストラクト | INTRODUCTION: Fractional CO(2) laser therapy is used to treat fibrosing conditions similar to Peyronie's disease (PD). The aim of the study was to evaluate the safety and efficacy of using a fractional CO(2) laser in the management of chronic phase PD. METHODS: This was a single-site, non-randomized, open-label study using a fractional CO(2) laser. Subjects underwent three treatment sessions every six weeks with a fractional CO(2) device. Topical triamcinolone was applied immediately after each treatment. Between treatments, patients performed penile modeling three times daily. Penile curvature assessments, self-reported questionnaires, and adverse event screenings were completed at baseline, 24 weeks, and 52 weeks. RESULTS: Five patients were included in the study. The median baseline penile curvature was 37.0 degrees (interquartile range [IQR] 33.0 degrees , 53.0 degrees ), and at 52 weeks, this had reduced to a median curvature of 28.0 degrees (IQR 17.50 degrees , 44.0 degrees , p=0.03), representing a median reduction in penile curvature by 24.3% (IQR 17.0%, 47.5%). The International Index of Erectile Function Overall scores were comparable at baseline and at 52 weeks (median 59.0, IQR 42.5, 66.5 vs. median 60.0, IQR 53.5, 70.0 respectively, p=0.81). Patients did report significant improvement in overall Peyronies' Disease Questionnaire scores from baseline to 52 weeks after laser treatment (median 26.0, IQR15.0, 29.5, vs. median 14.0, IQR 7.0, 22.50, respectively, p=0.03). Four patients reported self-limiting side effects immediately after laser therapy that resolved spontaneously within two weeks. CONCLUSIONS: With encouraging results at 52 weeks, fractional CO(2) laser therapy may serve as a well-tolerated and minimally invasive therapy for PD in the future. |
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| ジャーナル名 | Canadian Urological Association journal = Journal de l'Association des urologues du Canada |
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| Pubmed追加日 | 2024/10/18 |
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| 投稿者 | Chan, Justin Y H; Alhamam, Abdullah; Witherspoon, Luke; Rivers, Jason K; Flannigan, Ryan K |
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| 組織名 | Division of Urology, Department of Surgery, University of Toronto, Toronto, ON,;Canada.;Department of Urology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi;Arabia.;Division of Urology and Men's Health Centre, The Ottawa Hospital, Ottawa, ON,;Department of Dermatology and Skin Science, University of British Columbia,;Vancouver, BC, Canada.;Pacific Derm, Vancouver, BC, Canada.;Department of Urologic Sciences, University of British Columbia, Vancouver, BC, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39418492/ |
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