| アブストラクト | PURPOSE: People with pediatric and early adulthood type 1 diabetes (T1D) might have a higher fracture risk at several sites compared to the general population. Therefore, we assessed the hazard ratios (HR) of various fracture sites and determined the risk factors associated with fractures among people with newly diagnosed childhood and adolescence T1D. METHODS: All people from the UK Clinical Practice Research Datalink GOLD (1987-2017), below 20 years of age with a T1D diagnosis code (n = 3100) and a new insulin prescription, were included and matched 1:1 by sex, age, and practice to a control without diabetes. Cox regression was used to estimate HRs of any, major osteoporotic fractures (MOFs) and peripheral fractures (lower-arm and lower-legs) for people with T1D compared to controls. The analyses were adjusted for sex, age, diabetic complications, medication (glucocorticoids, anti-depressants, anxiolytics, bone medication, anti-convulsive), Charlson-comorbidity-index (CCI), hypoglycemia, falls and alcohol. T1D was further stratified by diabetes duration, presence of diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) and boys versus girls. RESULTS: The crude HRs for any fracture (1.30, CI95%: 1.11-1.51), lower-arm (1.22, CI95%: 1.00-1.48), and lower-leg fractures (1.54, CI95%: 1.11-2.13) were statistically significant increase in T1D compared to controls, but the effect disappeared in the adjusted analyses. For MOFs, no significant differences were seen. Risk factors in the T1D cohort were few, but the most predominantly one was a previous fracture (any fracture: 2.00, CI95%: 1.70-2.36; MOFs: 1.89, CI95%: 1.44-2.48, lower- arm fractures: 2.08, CI95%: 1.53-2.82 and lower-leg fractures: 2.08, CI95%: 1.34-3.25). Others were a previous fall (any fracture: 1.54, CI95%: 1.20-1.97), hypoglycemia (Any fracture: 1.46, CI95%: 1.21-1.77 and lower-leg fractures: 2.34, CI95%: 1.47-3.75), and anxiolytic medication (Any fracture: 1.52, CI95%: 1.10-2.11). Whereas girls had a lower risk compared to boys (Any fracture: 0.78, CI95%: 0.67-0.90 and lower-arm fractures; 0.51, CI95%: 0.38-0.68). The risk of any fracture in T1D did not increase with longer diabetes duration compared to controls (0-4 years: 1.20, CI95%: 1.00-1.44; 5-9 years: 1.17, CI95%: 0.91-1.50; <10 years: 0.83, CI95%: 0.54-1.27). Similar patterns were observed for other fracture sites. Furthermore, one complication compared to none in T1D correlated with a higher fracture risk (1 complication: 1.42, CI95%: 1.04-1.95). CONCLUSION: The overall fracture risk was not increased in pediatric and early adulthood T1D; instead, it was associated with familiar risk factors and specific diabetes-related ones. |
|---|
| ジャーナル名 | Bone |
|---|
| 投稿日 | 2023/12/29 |
|---|
| 投稿者 | Rasmussen, Nicklas H; Driessen, Johanna H M; Kvist, Annika Vestergaard; Souverein, Patrick C; van den Bergh, Joop P; Vestergaard, Peter |
|---|
| 組織名 | Steno Diabetes Center North Denmark, Aalborg University Hospital, Denmark.;Electronic address: nicklas.rasmussen@rn.dk.;NUTRIM Research School, Maastricht University, Maastricht, the Netherlands;;Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for;Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Department;of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+,;Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht;(CARIM), Maastricht University, Maastricht, the Netherlands.;Department of Endocrinology and Metabolism, Molecular Endocrinology & Stem Cell;Research Unit (KMEB), Odense University Hospital, Odense, Denmark; University of;Southern Denmark, Odense, Denmark; Steno Diabetes Center North Denmark, Aalborg;University Hospital, Aalborg, Denmark; Institute of Pharmaceutical Sciences,;Department of Chemistry and Applied Biosciences, ETH-Zurich, Zurich, Switzerland.;Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.;School for Nutrition and Translational Research in Metabolism (NUTRIM),;Maastricht University, Maastricht, the Netherlands; Department of Internal;Medicine, Division of Rheumatology, Maastricht University Medical Center+,;Maastricht, the Netherlands; Department of Internal Medicine, VieCuri Medical;Center, Venlo, the Netherlands.;Steno Diabetes Center North Denmark, Aalborg University Hospital, Denmark;;Department of Clinical Medicine and Endocrinology, Aalborg University Hospital,;Aalborg, Denmark. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38154765/ |
|---|
