| アブストラクト | As part of a collaborative project between the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention for the development of a web-based natural language processing (NLP) workbench, we created a corpus of 1000 Vaccine Adverse Event Reporting System (VAERS) reports annotated for 36,726 clinical features, 13,365 temporal features, and 22,395 clinical-temporal links. This paper describes the final corpus, as well as the methodology used to create it, so that clinical NLP researchers outside FDA can evaluate the utility of the corpus to aid their own work. The creation of this standard went through four phases: pre-training, pre-production, production-clinical feature annotation, and production-temporal annotation. The pre-production phase used a double annotation followed by adjudication strategy to refine and finalize the annotation model while the production phases followed a single annotation strategy to maximize the number of reports in the corpus. An analysis of 30 reports randomly selected as part of a quality control assessment yielded accuracies of 0.97, 0.96, and 0.83 for clinical features, temporal features, and clinical-temporal associations, respectively and speaks to the quality of the corpus. |
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| 投稿日 | 2018/6/9 |
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| 投稿者 | Foster, Matthew; Pandey, Abhishek; Kreimeyer, Kory; Botsis, Taxiarchis |
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| ジャーナル名 | Vaccine |
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| 組織名 | FDA Center for Biologics Evaluation and Research, Office of Biostatistics and;Epidemiology. 10903 New Hampshire Ave, Silver Spring, MD, United States.;Electronic address: matthew.foster@fda.hhs.gov.;Epidemiology. 10903 New Hampshire Ave, Silver Spring, MD, United States; The;Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of;Medicine, Baltimore, MD, United States. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/29880244/ |
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