| アブストラクト | INTRODUCTION: Previous studies have suggested an association between vaccines and autoimmune diseases, but they were limited by their narrow focus and timeframe. METHODS: This study conducted the first large-scale international analysis to investigate the impact of various vaccines on autoimmune liver diseases. Utilizing WHO's VigiBase data from 1968 to 2024, and the study identified 1,083 (0.012%) cases of vaccine-associated hepatic autoimmune disorders out of 8,562,584 reported vaccine adverse events. RESULTS: The vaccines with the highest risk of hepatic autoimmune disorders were the hepatitis B vaccine (reporting odds ratio [ROR], 3.52; 95% CI, 2.50-4.95), COVID-19 mRNA vaccines (ROR, 2.95; 95% CI, 2.73-3.18), and papillomavirus vaccines (ROR, 2.13; 95% CI, 1.45-3.13). Additionally, when vaccine-associated hepatic autoimmune disorders occurred, hepatobiliary adverse events were frequently observed to occur concurrently. CONCLUSIONS: This study suggests that vaccines may induce hepatic autoimmune disorders and highlights the need for enhanced monitoring before and after vaccination. Additionally, it proposes implementing pre-vaccination screening protocols and postvaccination monitoring to address this concern. |
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| 投稿者 | Jeong, Jinyoung; Jo, Hyesu; Park, Jaeyu; Smith, Lee; Rahmati, Masoud; Lee, Kwanjoo; Ha, Yeonjung; Yon, Dong Keon |
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| 組織名 | Department of Medicine, Kyung Hee University College of Medicine, Seoul, Republic;of Korea.;Center for Digital Health, Medical Science Research Institute, Kyung Hee;University Medical Center, Kyung Hee University College of Medicine, Seoul,;Republic of Korea.;Department of Regulatory Science, Kyung Hee University, Seoul, Republic of Korea.;Centre for Health, Performance and Wellbeing, Anglia Ruskin University,;Cambridge, UK.;Department of Physical Education and Sport Sciences, Faculty of Literature and;Human Sciences, Lorestan University, Khoramabad, Iran.;Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.;CEReSS-Health Service Research and Quality of Life Center, AP-HM-Assistance;Publique-Hopitaux de Marseille, Aix-Marseille University, Marseille, France.;Department of Gastroenterology, CHA Bundang Medical Center, CHA University School;of Medicine, Seongnam, Republic of Korea.;Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee;University College of Medicine, Seoul, Republic of Korea. |
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