| アブストラクト | OBJECTIVE: We aimed to evaluate glucose and prolactin monitoring in children and adolescents initiating antipsychotic therapy using a nationwide claims database. METHODS: A retrospective 15-month cohort study was conducted using the National Database of Health Insurance Claim Information and Specified Medical Checkups in Japan. Patients aged </=18 years, who were newly prescribed antipsychotics between April 2014 and March 2015, were followed up for 450 days. Outcomes were the use of glucose and prolactin testing through 15 months after drug initiation (index date) with consideration of persistence with antipsychotic therapy. The incidence proportion of patients monitored was assessed within the following four time windows: baseline (between 30 days before the index date and the index date), at 1-3 months (between 1 and 90 days after the index date), at 4-9 months (between 91 and 270 days after the index date), and at 10-15 months (between 271 and 450 days after the index date). RESULTS: Of 43,608 new users in 6620 medical institutions, the percentage of persistent antipsychotic users was 46.4% at 90 days, 29.7% at 270 days, and 23.8% at 450 days after the index date. The proportion of patients who received monitoring within the baseline period was 13.5% (95% confidence interval [CI], 13.2-13.8) for glucose and 0.6% (95% CI, 0.5-0.6) for prolactin, respectively. The proportion of patients who received glucose monitoring at all time windows decreased to 0.9%. The proportion of patients who received prolactin monitoring by the second time window decreased to 0.1%. CONCLUSIONS: Our study shows that monitoring for glucose and prolactin is infrequent in children and adolescents initiating antipsychotic therapy. Strategies for physicians, patients, and guardians are needed to overcome the barriers in glucose and prolactin monitoring. |
|---|
| 投稿者 | Okumura, Yasuyuki; Usami, Masahide; Okada, Takashi; Saito, Takuya; Negoro, Hideki; Tsujii, Noa; Fujita, Junichi; Iida, Junzo |
|---|
| 組織名 | 1 Research Department, Institute for Health Economics and Policy , Association;for Health Economics Research and Social Insurance and Welfare, Tokyo, Japan .;2 Department of Psychiatry and Behavioral Science, Tokyo Metropolitan Institute;of Medical Science , Tokyo, Japan .;3 Department of Child and Adolescent Psychiatry, Kohnodai Hospital, National;Center for Global Health and Medicine , Ichikawa, Japan .;4 Department of Child and Adolescent Psychiatry, Nagoya University Graduate;School of Medicine , Nagoya, Japan .;5 Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hokkaido;University , Sapporo, Japan .;6 Department of Professional Development in Education, Graduate School of;Professional Development in Education, Nara University of Education , Nara, Japan;.;7 Department of Neuropsychiatry, Kindai University Faculty of Medicine , Osaka,;Japan .;8 Department of Child Psychiatry, Yokohama City University Hospital , Yokohama,;9 Department of Human Development, Faculty of Nursing, Nara Medical University ,;Kashihara, Japan . |
|---|
