| アブストラクト | AIM: To investigate the association between glycaemic variability and the development of End-Stage-Kidney-Disease (ESKD) among individuals with diabetes and chronic kidney disease. METHODS: A cohort study using UK electronic primary care health records from the Clinical Practice Research Datalink. Glycaemic variability was assessed using a variability score and intra-individual coefficient of variation (CV) of HbA1c. We calculated sub-distribution hazard ratios (sHR) for developing ESKD using competing risk regression analysis. RESULTS: There were 37,222 eligible participants (45.5 % male), with a mean age of 76.4 years (SD +/- 9.2), and a mean baseline eGFR 40.7 (+/-10.7) ml/min/1.73 m(2). There were 5,086 incidents of ESKD in the follow-up period. The adjusted sHR (95 %CI) for each variability score group, were as follows: 21-40, 1.38 (1.27-1.50); 41-60, 1.54 (1.41-1.68); 61-80, 1.61 (1.45-1.79); and 81-100, 1.42 (1.19-1.68), compared with the group (score 0-20) with least variability. The adjusted sHR for CV were as follows: 6.7-9.9, 1.29 (1.15-1.45); 10.0-13.9, 1.55 (1.39-1.74); 14.0-20.1, 1.79 (1.60-2.01) and >/=20.2, 2.10 (1.88-2.34) compared to reference group 0-6.6. CONCLUSIONS: Glycaemic variability was strongly associated with the development of ESKD in people with diabetes and CKD. |
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| ジャーナル名 | Diabetes research and clinical practice |
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| Pubmed追加日 | 2022/10/16 |
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| 投稿者 | Habte-Asres, Hellena Hailu; Murrells, Trevor; Nitsch, Dorothea; Wheeler, David C; Forbes, Angus |
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| 組織名 | Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's;College London, London, UK. Electronic address: Hellena.Habete-Asres@kcl.ac.uk.;College London, London, UK.;Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and;Population Health, London School of Hygiene & Tropical Medicine Keppel Street,;London, UK.;Department of Renal Medicine, Royal Free Campus, University College London,;Rowland Hill Street, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36243232/ |
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