| アブストラクト | BACKGROUND: The COP28 Declaration on Climate and Health promotes steps to curb emissions and reduce waste in the health sector. OBJECTIVE: To describe and quantify greenhouse gas (GHG) emissions associated with severe asthma (SA) care in the UK, by carbon source and transition status from SA to severe uncontrolled asthma (SUA) and/or regular specialist care (RSC). METHODS: This was a cohort study using routinely collected data from the Clinical Practice Research Datalink Aurum, Hospital Episode Statistics and CO(2) equivalent emissions data. Patients were >/=12 years old at index date (i.e. date of first recorded ICS + controller prescription) with a validated asthma diagnosis. Total-, medication-, exacerbation- and healthcare resource utilisation (HCRU)-related GHG emissions were estimated, overall and by transition along stages of the SA-SUA-RSC continuum. Five pathways and stage orders were identified: 1. SA, 2. SA-SUA, 3. SA-RSC, 4. SA-RSC-SUA, 5. SA-SUA-RSC. RESULTS: Total CO(2) eq for the SA population (n=93,054) was 2167 tonnes/10K patients/year. GHG emissions were 5.2-23.0% greater for patients transitioned to SUA (versus previous stage), mostly due to exacerbation-related emissions (4.2-7.7 times greater; predominantly hospitalizations) and medication-related emissions (3.5-10.9% greater; predominantly SABAs). Conversely, total GHG emissions decreased by 12.1-23.9% for those referred to RSC, due to decreased exacerbation-related emissions (1.7-5.2 times lower; all sources) and medication-related emissions (14.8-20.6% lower; both SABA and overall ICS). CONCLUSION: Our findings suggest that RSC not only improves patient outcomes but also reduces GHG emissions in line with aims to reduce the health sector's contribution to the total national carbon footprint. |
|---|
| ジャーナル名 | The journal of allergy and clinical immunology. In practice |
|---|
| Pubmed追加日 | 2025/2/24 |
|---|
| 投稿者 | Wilkinson, Alex; Khezrian, Mina; Heaney, Liam G; Patel, Soram; Quint, Jennifer K; Rupani, Hitasha; Rapsomaniki, Eleni; Rhodes, Kirsty; Menzies-Gow, Andrew N; Tran, Trung N |
|---|
| 組織名 | Department of Respiratory Medicine, Stevenage, East and North Hertfordshire NHS;Trust, Hertfordshire, UK.;Biopharmaceuticals Medical, AstraZeneca, Cambridge, UK.;Wellcome-Wolfson Institute for Experimental Medicine, Queen's University,;Belfast, UK.;School of Public Health, Imperial College London, London, UK.;Department of Respiratory Medicine, University Hospital Southampton NHS;Foundation Trust, Southampton, UK.;Real World Science, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.;BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA. Electronic;address: trung.tran1@astrazeneca.com. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39988069/ |
|---|
