| アブストラクト | BACKGROUND: There are isolated reports of Guillain-Barre syndrome (GBS) after receiving vaccination. OBJECTIVE: To determine the rates and characteristics of GBS after administration of vaccination in United States METHODS: We used data for 1990 to 2005 from the Vaccine Adverse Event Reporting System, which is a cooperative program of the Centers for Disease Control and Prevention and the US Food and Drug Administration. RESULTS: There were 1000 cases (mean age, 47 years) of GBS reported after vaccination in the United States between 1990 and 2005. The onset of GBS was within 6 weeks in 774 cases, >6 weeks in 101, and unknown in 125. Death and disability after the event occurred in 32 (3.2%) and 167 (16.7%) subjects, respectively. The highest number (n = 632) of GBS cases was observed in subjects receiving influenza vaccine followed by hepatitis B vaccine (n = 94). Other vaccines or combinations of vaccines were associated with 274 cases of GBS. The incidence of GBS after influenza vaccination was marginally higher in subjects <65 years compared with those >or=65 years (P = 0.09); for hepatitis vaccine, the incidence was significantly higher (P < 0.0001) in the <65 group. Death was more frequent in subjects >or=65 years compared with those <65 years (P < 0.0001). CONCLUSIONS: Our results suggest that vaccines other than influenza vaccine can be associated with GBS. Vaccination-related GBS results in death or disability in one fifth of affected individuals, which is comparable to the reported rates in the general GBS population. |
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| 投稿日 | 2009/9/5 |
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| 投稿者 | Souayah, Nizar; Nasar, Abu; Suri, M Fareed K; Qureshi, Adnan I |
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| ジャーナル名 | Journal of clinical neuromuscular disease |
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| 組織名 | Epidemiological and Outcomes Research Division, Zeenat Qureshi Stroke Research;Center, Department of Neurology, University of Medicine and Dentistry of New;Jersey, Newark, NJ, USA. souayani@umdnj.edu |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/19730016/ |
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