| アブストラクト | BACKGROUND: Narcolepsy is a chronic disorder that requires lifelong management; however, few studies have evaluated disease burden of narcolepsy. We estimated the healthcare burden of narcolepsy in Japan using data from the Japan Medical Data Center health insurance claims database. METHODS: This was a retrospective analysis of clinical burden, healthcare resource utilization, and costs among incident narcolepsy cases and matched controls identified between January 1, 2014 and December 31, 2019. RESULTS: Of the 1317 incident cases; 889 (with 1778 controls) were analyzed for healthcare burden, 626 (with 1252 controls) for clinical journey, and 439 (no controls) for treatment patterns. The most common baseline comorbidity was non-narcolepsy sleep disorder (41.6 % cases vs 3.0 % controls), including insomnia (28.5 % vs 2.6 %) and sleep apnea (10.8 % vs 0.3 %; both p < 0.001). The most common nonsleep disorder comorbidities were depression (35.0 % vs 2.6 %), anxiety (30.4 % vs 2.7 %), and headache/migraine (18.1 % vs 5.5 %; all p < 0.001). Compared to controls, narcolepsy cases had more prescription claims in the year following index date (82.8 % vs 9.5 %; p < 0.001), higher rates of outpatient (2291.8 vs 674.9 visits/100 person-years; p < 0.001) and inpatient claims (56.8 vs 5.1/100 person-years; p < 0.001), and longer hospital stays (mean 2.9 vs 0.5 days; p < 0.001). Similarly, median HCRU costs were higher in cases than controls (total annual healthcare costs, $2531 vs $266; community pharmacy claims, $826 vs $47 per person; and outpatient claim costs, $1053 vs $188 per person year). CONCLUSIONS: Narcolepsy carries a substantial comorbidity burden, a high rate of medication prescribing, and high healthcare resource use in Japan. |
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| ジャーナル名 | Sleep medicine |
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| Pubmed追加日 | 2025/1/15 |
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| 投稿者 | Kadotani, Hiroshi; Matsuo, Masahiro; Tran, Lucy; Parsons, Victoria L; Maguire, Andrew; Ghosh, Somraj; Crawford, Stephen; Dave, Shreya |
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| 組織名 | Department of Psychiatry, Shiga University of Medical Science,;Seta-Tsukinowa-cho, Otsu, Japan.;Takeda Pharmaceutical Company Limited, Osaka, Japan.;Epifocus Limited, Wanstead, London, UK.;Takeda Development Center Americas, Inc., Cambridge, MA, USA.;Takeda Development Center Americas, Inc., Cambridge, MA, USA. Electronic address:;Stephen.Crawford@takeda.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39809067/ |
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