| アブストラクト | OBJECTIVE: Using a retrospective cohort study, the mean length of hospital stay (LoS) and total per-patient expenditure for hypoglycemia requiring admission to hospital were estimated. In a separate matched retrospective cohort study, the effect of inpatient hypoglycemia on LoS, expenditure, and risk of all-cause mortality while admitted was investigated. METHODS: The cohorts consisted of patients aged >/=18 years with a diagnosis of type 1 or 2 diabetes between January 1, 2002 and October 30, 2012 in the Clinical Practice Research Datalink database, who had initiated insulin treatment and had a recording of hypoglycemia in the same period. In the matched retrospective cohort study, exposed patients (who experienced hypoglycemia in hospital) were case-matched with patients who did not experience hypoglycemia during admission (unexposed). Generalized linear regression was used to estimate LoS. Risk of all-cause mortality was evaluated via logistic regression. RESULTS: In the retrospective cohort study (1131 patients), mean LoS was 5.46 (95% CI 4.62 to 6.45) days for type 1 diabetes, and 5.04 (95% CI 4.46 to 5.71) days for type 2 diabetes. Mean cost per admission was pound1034 (95% CI pound855 to pound1253). In the matched retrospective cohort study (1079 pairs of patients), exposed patients had a mean LoS of 11.91 days (95% CI 10.96 to 12.94 days) versus 4.80 (95% CI 4.41 to 5.23) for unexposed patients, p<0.0001. Exposed patients had a higher mortality risk compared with unexposed patients (OR 1.439 (95% CI 1.060to 1.952), p=0.0195). Total average per-patient cost for exposed patients was GBP ( pound)2235, 40% (p<0.0001) higher than total average admission cost in unexposed patients. CONCLUSIONS: Hypoglycemia has a significant negative impact on patient outcomes, healthcare resource use, and expenditure. |
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| ジャーナル名 | BMJ open diabetes research & care |
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| Pubmed追加日 | 2015/03/31 |
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| 投稿者 | McEwan, Philip; Larsen Thorsted, Brian; Wolden, Michael; Jacobsen, Judith; Evans, Marc |
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| 組織名 | Swansea University , Swansea , UK.;Novo Nordisk A/S , Bagsvaerd , Denmark.;Statcon ApS , Kokkedal , Denmark.;Llandough Hospital , Cardiff , UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25815204/ |
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