| アブストラクト | AIMS/INTRODUCTION: We investigated the utilization of healthcare resources in patients with type 2 diabetes treated with empagliflozin, a sodium-glucose co-transporter-2 (SGLT2) inhibitor, versus dipeptidyl peptidase-4 (DPP-4) inhibitors in clinical practice in Japan, South Korea, and Taiwan. MATERIALS AND METHODS: We analyzed the Japanese Medical Data Vision database (December 2014-April 2018), the South Korean National Health Information Database, and the Taiwanese National Health Insurance claims database (both May 2016-December 2017). Patients with type 2 diabetes starting empagliflozin, 10 or 25 mg, or a DPP-4 inhibitor were matched 1:1 via propensity scores (PS). We compared inpatient care needs, emergency room (ER) visits, and outpatient visits between the treatment groups using Poisson regression and Cox proportional hazards models, pooled across countries by random-effects meta-analysis. RESULTS: We identified 28,712 pairs of PS-matched patients; the mean follow-up was 5.7-6.8 months. Empagliflozin-treated patients had a 27% lower risk of all-cause hospitalization compared with DPP-4 inhibitor-treated patients (rate ratio [RR] 0.73, 95% CI 0.67-0.79), and 23% reduced risk for first hospitalization (hazard ratio 0.77, 95% CI 0.73-0.81). The risk for an ER visit was 12% lower with empagliflozin than with DPP-4 inhibitors (RR 0.88, 95% CI 0.83-0.94) while the risk for outpatient visit was 4% lower (RR 0.96, 95% CI 0.96-0.97). These findings were generally consistent across countries, regardless of baseline cardiovascular disease, and in the subgroup starting empagliflozin with the 10 mg dose. CONCLUSIONS: Empagliflozin treatment was associated with lower inpatient care needs and other healthcare resource utilization than DPP-4 inhibitors in routine clinical practice in East Asia in this study. |
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| 投稿者 | Sheu, Wayne H-H; Seino, Yutaka; Tan, Elise Chia-Hui; Yabe, Daisuke; Ha, Kyoung Hwa; Nangaku, Masaomi; Chung, Wook-Jin; Node, Koichi; Yasui, Atsutaka; Lei, Wei-Yu; Lee, Sunwoo; Ustyugova, Anastasia; Klement, Riho; Deruaz-Luyet, Anouk; Kyaw, Moe H; Kim, Dae Jung |
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| 組織名 | Division of Endocrinology and Metabolism, Taipei Veterans General Hospital,;Taipei, Taiwan.;Kansai Electric Power Medical Research Institute, Kobe, Japan.;Kansai Electric Power Hospital, Osaka, Japan.;National Research Institute of Chinese Medicine, Ministry of Health and Welfare,;Institute of Hospital and Healthcare Administration, National Yang-Ming;University, Taipei, Taiwan.;Department of Diabetes, Endocrinology and Metabolism, and Department of;Rheumatology and Clinical Immunology, Gifu University Graduate School of;Medicine, Gifu, Japan.;Division of Metabolism and Molecular Medicine, Kobe University Graduate School of;Medicine, Kobe, Japan.;Department of Endocrinology and Metabolism, Ajou University School of Medicine,;Suwon, Korea.;Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.;Department of Cardiovascular Medicine, Gachon University Gil Medical Center,;Incheon, Korea.;Department of Cardiovascular Medicine, Saga University, Saga, Japan.;Nippon Boehringer Ingelheim Co., Ltd, Tokyo, Japan.;Boehringer Ingelheim Taiwan Ltd, Taipei, Taiwan.;Boehringer Ingelheim Korea Ltd, Seoul, Korea.;Boehringer Ingelheim International GmbH, Ingelheim, Germany.;Global Database Studies, IQVIA, Tartu, Estonia.;Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, USA. |
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