| アブストラクト | OBJECTIVES: We aimed to evaluate and compare the risk of hematological adverse events (AEs) associated with CDK4/6 inhibitors using data from randomized controlled trials (RCTs) and Food and Drug Adverse Event Reporting System (FAERS) database. METHODS: The PubMed, Embase, and Cochrane Library databases were searched for RCTs related to abemaciclib, palbociclib, and ribociclib. A network meta-analysis (NMA) was conducted to compare the risks of hematological AEs, and a disproportionality analysis was performed to detect signals of hematological AEs. RESULTS: 16 RCTs comprising 16,350 breast cancer patients were included. Palbociclib and ribociclib had similar risks for hematological AEs, except a higher risk of grade 3-4 leukopenia observed with palbociclib (risk ratio [RR]: 7.84, 95% confidence interval [95%CI]: 1.33-41.28). Abemaciclib had a higher risk of anemia than both ribociclib (grade 1-4: 2.23, 95% CI: 1.25 - 3.96; grade 3-4: 3.52, 95% CI: 1.59 - 8.11) and palbociclib (grade 1-4: 1.65, 95%CI: 1.03 - 2.59), but a lower risk of grade 3-4 of both leukopenia (0.12, 95%CI: 0.02 - 0.49) and neutropenia (0.15, 95%CI: 0.04 - 0.52) compared with palbociclib. Signals indicating occurrence of leukopenia, neutropenia, anemia, and thrombocytopenia were identified for three CDK4/6 inhibitors. CONCLUSION: Abemaciclib, palbociclib, and ribociclib showed significant but inconsistent hematological toxicity risks. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2024/5/16 |
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| 投稿者 | Ding, Haiying; Xu, Weiben; Dai, Mengfei; Li, Shujing; Xin, Wenxiu; Tong, Yinghui; He, Chaoneng; Mi, Xiufang; Zhan, Zhajun; Fang, Luo |
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| 組織名 | Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine;(HIM), Chinese Academy of Sciences, Hangzhou, China.;College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou,;China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38753541/ |
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