| アブストラクト | BACKGROUND: Recently, there have been clinical reports of hepatitis B virus reactivation (HBVr) related with Janus kinase (JAK) inhibitors. However, there were no studies to investigate the association between HBVr and different JAK inhibitors. RESEARCH DESIGN AND METHODS: This study was a retrospective review utilizing the FAERS pharmacovigilance database and a systematic literature search for all cases of HBVr reported with JAK inhibitors. Disproportionality analysis and Bayesian analysis were used in data detection to screen the suspected HBVr after the administration of different JAK inhibitors, based on the FDA Adverse Event Reporting System (FAERS) pharmacovigilance database from Q4 2011 to Q1 2022. RESULTS: There were a total number of 2097 (0.02%) reports of HBVr in FAERS, of which 41 (1.96%) were associated with JAK inhibitors. Baricitinib appeared to have the strongest signal among four JAK inhibitors, based on the highest reporting odds ratio (ROR = 4.45, 95% confidence interval [CI] 1.67-11.89). Ruxolitinib also showed signals, whereas no signals were detected among Tofacitinib and Upadacitinib. CONCLUSION: While there may be an association between JAK inhibitors and HBVr, it appears to be a numerically uncommon occurrence. Further studies are needed to optimize the safety profiles of JAK inhibitors. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2023/2/17 |
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| 投稿者 | Pan, Chen; Cao, Mingnan; Yan, Cilin; Ou, Xiaojuan; Zhang, Xia; Xu, Wanyi; Xu, Ye; Cui, Xiangli |
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| 組織名 | Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University,;Beijing, China.;Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University,;School of Automation Science and Electrical Engineering, Beihang University,;National Clinical Research Center for Digestive Diseases, Beijing, China.;Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, Liver;Research Center, Beijing Friendship Hospital, Capital Medical University,;Department of Rheumatology, Beijing Friendship Hospital, Capital Medical;University, Beijing, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36794347/ |
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