| アブストラクト | INTRODUCTION: The role of gender, age, dose and other factors in the adverse reaction process of pseudocholelithiasis caused by ceftriaxone is controversial. In this study, we further explored potential risk factors using the FAERS database. METHODS: The reported odds ratio (ROR) and the information component (IC) of specific candidate factors were calculated by using the ROR method and the Bayesian confidence promotion neural network (BCPNN) method respectively to detect potential risk factors in adverse events(AEs) of ceftriaxone and hepatobiliary calculi(HBC). One candidate factor will be considered as a suspicious signal, or potential risk factors if its lower limit of 95% confidence interval of ROR (ROR025) is greater than 1 and its lower limit of 95% confidence interval of IC (IC025) is greater than 0. RESULTS: A total of 764 AEs of HBC were used to this analysis to evaluate candidate risk factors: Age group, Gender, Dose. Child (1-12 years): male ROR025 = 6.64, IC025 = 2.42, female ROR025 = 6.66, IC025 = 2.40. Adolescent group (12-18 years): male ROR025 = 5.47, IC025 = 2.08; elderly (>/=65 years): female ROR025 = 1.25, IC025 = 0.22. CONCLUSIONS: Gender was not detected as a risk factor for HBC caused by ceftriaxone. However, Male infants, male children, female children, adolescent male, and elderly female were potential risk factors for HBC caused by ceftriaxone based on criteria ROR025 > 1 and IC025 > 0. |
|---|
| ジャーナル名 | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
|---|
| Pubmed追加日 | 2022/10/22 |
|---|
| 投稿者 | Liu, Xin; Xu, Ze; Ma, Juman; Zhang, Aijun; Li, Zhaohang; Qi, Guanpeng; Li, Zuojing; Wei, Fenfang; Zhong, Ling |
|---|
| 組織名 | School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical;University, Liaoning, Shenyang, 110000, China.;School of Pharmacy, Shenyang Pharmaceutical University, Liaoning, Shenyang,;110000, China.;School of Medical Devices, Shenyang Pharmaceutical University, Shenyang,;Liaoning, 110000, China. Electronic address: zuojing1006@hotmail.com.;Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, Guangdong,;518000, China. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36270450/ |
|---|
