| アブストラクト | BACKGROUND: A few cases of Herpes Zoster and Simplex reactivation following COVID-19 immunization have been recently described, but the real extent of this suspected adverse event has not been elucidated yet. METHODS: We performed a nested case/control study by using the U.S. Vaccine Adverse Event Reporting System database. We carried out a case-level clinical review of all Herpes reactivation cases following the administration of COVID-19 vaccines. For cases and controls, significance was set at P = 0.05, differential risk of reporting was assessed for each vaccine as reporting odds ratio and incidence was estimated based on the total number of vaccine doses administered. RESULTS: Of 6,195 cases included in the analysis (5,934 and 273 reporting Herpes Zoster and Herpes Simplex, respectively) over 90% were non-serious. We found a slightly higher risk of reporting both for Zoster (ROR = 1.49) and Simplex (ROR = 1.51) infections following the Pfizer-BioNTech vaccine. The estimated incidence was approximately 0.7/100,000 and 0.03/100,000 for Zoster and Simplex, respectively. CONCLUSIONS: The paucity of cases (almost all of non-serious nature) makes the potential occurrence of this adverse effect negligible from clinical standpoints, thus supporting the good safety profile of the COVID-19 vaccination, which remains strongly recommended. |
|---|
| ジャーナル名 | Expert review of vaccines |
|---|
| Pubmed追加日 | 2022/2/23 |
|---|
| 投稿者 | Gringeri, Michele; Battini, Vera; Cammarata, Gianluca; Mosini, Giulia; Guarnieri, Greta; Leoni, Chiara; Pozzi, Marco; Radice, Sonia; Clementi, Emilio; Carnovale, Carla |
|---|
| 組織名 | Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences L.;Sacco, "Luigi Sacco" University Hospital, University of Milan, Milano, Italy.;Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35191364/ |
|---|
