| アブストラクト | INTRODUCTION: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. CASE REPORT: We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. CONCLUSION: Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine. |
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| ジャーナル名 | La Revue de medecine interne |
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| 投稿日 | 2016/10/18 |
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| 投稿者 | Chatelet, J-N; Auffret, M; Combret, S; Bondon-Guitton, E; Lambert, M; Gautier, S |
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| 組織名 | Centre regional de pharmacovigilance de Lille, CHRU de Lille, 1, place de Verdun,;59045 Lille cedex, France.;59045 Lille cedex, France. Electronic address: ma.auffret@gmail.com.;Centre regional de pharmacovigilance de Dijon, CHU de Dijon, 21079 Dijon cedex;France.;Centre regional de pharmacovigilance de Toulouse, CHU de Toulouse, 31000 Toulouse;Service de medecine Interne, hopital Claude-Huriez, CHRU de Lille, 59045 Lille;cedex France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/27745936/ |
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