| アブストラクト | Sleep disordered breathing (SDB), mainly obstructive sleep apnea (OSA), constitutes a major health problem due to the large number of patients. Intermittent hypoxia caused by SDB induces alterations in metabolic function. Nevertheless, metabolites characteristic for SDB are largely unknown. In this study, we performed gas chromatography-mass spectrometry-based targeted metabolome analysis using data from The Nagahama Study (n = 6373). SDB-related metabolites were defined based on their variable importance score in orthogonal partial least squares discriminant analysis and fold changes in normalized peak-intensity levels between moderate-severe SDB patients and participants without SDB. We identified 20 metabolites as SDB-related, and interestingly, these metabolites were frequently included in pathways related to fructose. Multivariate analysis revealed that moderate-severe SDB was a significant factor for increased plasma fructose levels (beta = 0.210, P = 0.006, generalized linear model) even after the adjustment of confounding factors. We further investigated changes in plasma fructose levels after continuous positive airway pressure (CPAP) treatment using samples from patients with OSA (n = 60) diagnosed by polysomnography at Kyoto University Hospital, and found that patients with marked hypoxemia exhibited prominent hyperfructosemia and their plasma fructose levels lowered after CPAP treatment. These data suggest that hyperfructosemia is the abnormality characteristic to SDB, which can be reduced by CPAP treatment. |
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| 投稿者 | Nakatsuka, Yoshinari; Murase, Kimihiko; Sonomura, Kazuhiro; Tabara, Yasuharu; Nagasaki, Tadao; Hamada, Satoshi; Matsumoto, Takeshi; Minami, Takuma; Kanai, Osamu; Takeyama, Hirofumi; Sunadome, Hironobu; Takahashi, Naomi; Nakamoto, Isuzu; Tanizawa, Kiminobu; Handa, Tomohiro; Sato, Taka-Aki; Komenami, Naoko; Wakamura, Tomoko; Morita, Satoshi; Takeuchi, Osamu; Nakayama, Takeo; Hirai, Toyohiro; Kamatani, Yoichiro; Matsuda, Fumihiko; Chin, Kazuo |
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| 組織名 | Department of Respiratory Care and Sleep Control Medicine, Graduate School of;Medicine, Kyoto University, Kyoto, Japan.;Center for Genomic Medicine, Graduate School of Medicine, Kyoto University,;Kyoto, Japan.;Graduate School of Public Health, Shizuoka Graduate University of Public Health,;Shizuoka, Japan.;Department of Advanced Medicine for Respiratory Failure, Graduate School of;Department of Respiratory Medicine, Saiseikai Noe Hospital, Osaka, Japan.;Department of Primary Care and Emergency Medicine, Graduate School of Medicine,;Kyoto University, Kyoto, Japan.;Division of Respiratory Medicine, Center for Respiratory Diseases, National;Hospital Organization Kyoto Medical Center, Kyoto, Japan.;Nursing Science, Human Health Sciences, Graduate School of Medicine, Kyoto;University, Kyoto, Japan.;Department of Respiratory Medicine, Graduate School of Medicine, Kyoto;Life Science Research Center, Technology Research Laboratory, Shimadzu;Corporation, Kyoto, Japan.;Department of Food and Nutrition, Kyoto Women's University, Kyoto, Japan.;Department of Biomedical Statistics and Bioinformatics, Graduate School of;Department of Medical Chemistry, Graduate School of Medicine, Kyoto University,;Department of Health Informatics, Kyoto University School of Public Health,;Kyoto, Japan. chin.kazuo@nihon-u.ac.jp.;Department of Sleep Medicine and Respiratory Care, Division of Respiratory;Medicine, Nihon University of Medicine, 1-30, Uemachi Otaniguchi Itabashi-Ku,;Tokyo, 173-8610, Japan. chin.kazuo@nihon-u.ac.jp. |
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