| アブストラクト | PURPOSE: Antibiotics are widely used in the management of bacterial infections However; most antibiotics are not known for DRESS. Our objective is to find out the association of DRESS with available antibiotics using disproportionality analysis. METHODS: Retrospective pharmacovigilance disproportionality analysis based on the FDA Adverse Event Reporting System (FAERS) database from a period of 2004 Q1- 2022 Q3 was conducted using OpenVigil 2.1 tool. Disproportionality measures like Proportional reporting Ratio with associated Chi- square values (PRR >/= 2 with associated chi2 >/= 4), ROR with a 95% confidence interval (lower limit of 95% C.I. of ROR is greater than 1), and the number of cases of co-occurrence (n) were used for the identification of novel signals. RESULTS: A total of 13,918 cases of DRESS were reported, out of which 5,455 cases were found with various classes of antibiotics. The signal of DRESS was identified with a total of 40 antibiotics. Sub groups analysis results have shown variation in the strength of signal based on gender, age groups and geographical locations. The sensitivity analysis results have shown a decrease in the strength of signal after removal of cases of concomitant drugs. CONCLUSION: 22 antibiotics were identified which can be associated with DRESS; however, further causality assessment is required to confirm the association. |
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| ジャーナル名 | European journal of clinical pharmacology |
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| Pubmed追加日 | 2026/1/17 |
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| 投稿者 | Goyal, Khushi; Sharma, Ruchika; Datusalia, Ashok Kumar; Khatik, Gopal L; Kumar, Anoop |
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| 組織名 | Department of Pharmaceutical Biotechnology, Delhi Pharmaceutical Sciences and;Research University (DPSRU), New Delhi, India.;Centre for Precision Medicine and Pharmacy, Delhi Pharmaceutical Sciences and;Department of Pharmacology and Toxicology, National Institute of Pharmaceutical;Education and Research (NIPER), Raebareli, India.;Department of Medicinal Chemistry, National Institute of Pharmaceutical Education;and Research (NIPER), Raebareli, India.;Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and;Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPSRU),;New Delhi, 110017, India. abitmesra@gmail.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41546760/ |
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