| アブストラクト | BACKGROUND: Kidney transplant recipients with cancer are at higher risk of kidney transplant rejection (KTR), and the safety of immune checkpoint inhibitors (ICIs) is unclear. The present study investigates the relationship between ICIs and KTR using data from the Food and Drug Administration Adverse Event Reporting System (FAERS). RESEARCH DESIGN AND METHODS: Case reports of KTR inducted by ICIs in FAERS from 1 January 2011, to 30 June 2021, were collected, and a disproportionate analysis was performed to assess the correlation between ICIs and KTR. RESULTS: A total of 99 cases of ICI-related KTR were reported in the FAERS database. Most of them were male patients (n = 63, 84.0%), and more than half of patients suffered from malignant melanoma (n = 46, 52.9%). The median onset time after the medication was 22 days, the withdrawal rates of ICIs were 78.0%, and the overall death rate was 29.3%. In general, there was a significant relevance between ICIs and KTR (ROR = 3.92[3.21-4.79] IC025 = 1.56), of which PD-1 was the most prominent (n = 81 ROR = 5.26[4.22-6.57] IC025 = 1.86). CONCLUSIONS: ICIs may increase the risk of KTR in organ transplant recipients with cancer. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2022/8/6 |
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| 投稿者 | Wu, Junyan; Huang, Jianxiang; Zhu, Jianhong; He, Zhichao; Chen, Mengting; Gao, Siyuan; Liang, Dan; Yu, Xiaoxia; Lu, Chengyu |
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| 組織名 | School of Pharmacy, Guangdong Medical University, Zhanjiang, Guangdong, China.;Department of Pharmacy, Sun-Yat-Sen Memorial Hospital, Sun Yat-sen University,;Guangzhou, Guangdong, China.;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene;Regulation Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou,;Guangdong, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35929998/ |
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