| アブストラクト | This study further approaches immune-related interstitial lung disease adverse event in patients undergoing immune checkpoint inhibitor (ICI) monotherapy, ICI plus chemotherapy and ICI plus anti-VEGF therapy in the postmarketing period. Reports for ICI-related interstitial lung disease adverse event from the FDA Adverse Event Reporting System (FAERS) database between 2014 and 2022 were analysed in this study. The reporting odds ratio (ROR) and Bayesian confidence propagation neural networks of information components (IC) were computed to identify disproportionate reporting of ICI-related interstitial lung disease. 44,964,609 records were extracted from the FAERS database, with 9150 records for interstitial lung disease after ICI treatment. Men had a slightly higher reporting frequency than women (63.07% vs. 25.69%). The morbidity rate (2.05%) of acute respiratory distress syndrome was low, the fatality rate (67.55%) was the highest, the time to onset was relatively short. Within 3 months, the cumulative proportion of ICI-related interstitial lung disease records was 75.03%. The ICI plus anti-VEGF therapy group had the lowest frequency of interstitial lung disease adverse events compared to the ICI monotherapy group and the ICI plus chemotherapy group (IC(025) = 1.72, IC(025) = 3.21, IC(025) = 3.22). Moreover, ICI plus anti-VEGF therapy group had the narrowest spectrum of interstitial lung disease among these three therapeutic regimens. This study showed substantial characteristics of a spectrum of interstitial lung disease adverse events after different ICI regimens. Notably, ICI plus anti-VEGF therapy might be a treatment method that can to some extent control ICI-related interstitial lung disease. These data provide some important information for clinicians to weigh the risks and benefits of different ICI regimens. |
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| ジャーナル名 | European journal of pharmacology |
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| 投稿日 | 2023/2/4 |
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| 投稿者 | Cui, Chanjuan; Zhang, Siyu; Ren, Xiayang; Cui, Wei; Wang, Yanfeng |
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| 組織名 | Department of Laboratory Medicine, National Cancer Center/ National Clinical;Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences;and Peking Union Medical College, Panjiayuan Street, Chaoyang District, Beijing,;100021, China. Electronic address: chanjuancui@126.com.;Department of Laboratory Medicine, Peking University Third Hospital. 49 Huayuan;North Road, Haidian District Beijing, 100191, China. Electronic address:;decadent4801@163.com.;Department of Pharmacy, National Cancer Center and Cancer Hospital, Chinese;Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021,;China. Electronic address: erxia100@163.com.;100021, China. Electronic address: cui123@cicams.ac.cn.;Department of Comprehensive Oncology, National Cancer Center/National Clinical;100021, China. Electronic address: wangyf@cicams.ac.cn. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36736527/ |
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