| アブストラクト | The potential antimicrobial and anti-inflammatory effectiveness of azithromycin against severe influenza is yet unclear. We retrospectively investigated the effect of intravenous azithromycin administration within 7 days of hospitalization in patients with influenza virus pneumonia and respiratory failure. Using Japan's national administrative database, we enrolled and classified 5066 patients with influenza virus pneumonia into severe, moderate, and mild groups based on their respiratory status within 7 days of hospitalization. The primary endpoints were total, 30-day, and 90-day mortality rates. The secondary endpoints were the duration of intensive-care unit management, invasive mechanical ventilation, and hospital stay. The inverse probability of the treatment weighting method with estimated propensity scores was used to minimize data collection bias. Use of intravenous azithromycin was proportional to the severity of respiratory failure (mild: 1.0%, moderate: 3.1%, severe: 14.8%). In the severe group, the 30-day mortality rate was significantly lower with azithromycin (26.49% vs. 36.65%, p = 0.038). In the moderate group, the mean duration of invasive mechanical ventilation after day 8 was shorter with azithromycin; there were no significant differences in other endpoints between the severe and moderate groups. These results suggest that intravenous azithromycin has favorable effects in patients with influenza virus pneumonia using mechanical ventilation or oxygen. |
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| ジャーナル名 | Viruses |
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| 投稿日 | 2023/5/27 |
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| 投稿者 | Tokito, Takatomo; Kido, Takashi; Muramatsu, Keiji; Tokutsu, Kei; Okuno, Daisuke; Yura, Hirokazu; Takemoto, Shinnosuke; Ishimoto, Hiroshi; Takazono, Takahiro; Sakamoto, Noriho; Obase, Yasushi; Ishimatsu, Yuji; Fujino, Yoshihisa; Yatera, Kazuhiro; Fushimi, Kiyohide; Matsuda, Shinya; Mukae, Hiroshi |
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| 組織名 | Department of Respiratory Medicine, Nagasaki University Graduate School of;Biomedical Sciences, Nagasaki 852-8501, Japan.;Department of Preventive Medicine and Community Health, University of;Occupational and Environmental Health, Japan, Kitakyushu 807-0804, Japan.;Department of Infectious Diseases, Nagasaki University Graduate School of;Department of Nursing, Nagasaki University Graduate School of Biomedical;Sciences, Nagasaki 852-8501, Japan.;Department of Environmental Epidemiology, Institute of Industrial Ecological;Science, University of Occupational and Environmental Health, Japan, Kitakyushu;807-0804, Japan.;Department of Respiratory Medicine, University of Occupational and Environmental;Health, Japan, Kitakyushu 807-0804, Japan.;Department of Health Policy and Informatics, Graduate School of Medical and;Dental Sciences, Tokyo Medical and Dental University, Japan, Tokyo 113-8519,;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37243228/ |
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