Impact of congenital heart disease on outcomes after primary repair of esophageal atresia: a retrospective observational study using a nationwide database in Japan.
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アブストラクト PURPOSE:To verify the association between congenital heart disease (CHD) and postoperative complications after primary repair of esophageal atresia in patients from a Japanese nationwide database.METHODS:We identified babies in the Diagnosis Procedure Combination database who underwent radical surgery for esophageal atresia from 2010 to 2016. We used multivariable logistic regression analyses to evaluate the occurrence of anastomotic leakage and anastomotic stricture.RESULTS:Among 431 patients who underwent primary anastomosis, 114 patients (27%) had CHD. Anastomotic leakage occurred in 77 patients (17.9%) and stricture in 154 (35.7%). Compared with patients whose anesthetic duration was less than 240 min, those with anesthesia lasting from 240 to 360 min (odds ratio 2.49; 95% confidence interval (CI) 1.17-5.27; p = 0.02) or more than 360 min (odds ratio 4.10; 95% CI 1.69-9.96; p = 0.002) were more likely to experience anastomotic leakage. Male patients had a lower risk of anastomotic stricture than female patients (odds ratio 0.65; 95% CI 0.43-0.9; p = 0.04).CONCLUSIONS:CHD was not associated with anastomotic leakage or stricture. The only significant predictor of anastomotic leakage was duration of anesthesia.ジャーナル名 Pediatric surgery international Pubmed追加日 2019/8/10 投稿者 Ishimaru, Tetsuya; Fujiogi, Michimasa; Michihata, Nobuaki; Matsui, Hiroki; Fushimi, Kiyohide; Kawashima, Hiroshi; Fujishiro, Jun; Yasunaga, Hideo 組織名 Department of Pediatric Surgery, Saitama Children's Medical Center, 1-2;Shintoshin, Chuo-ku, Saitama, 330-8777, Japan. i-tetsuya@umin.ac.jp.;Department of Pediatric Surgery, Graduate School of Medicine, The University of;Tokyo, Tokyo, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School, Tokyo, Japan.;Shintoshin, Chuo-ku, Saitama, 330-8777, Japan. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/31396739/ -
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