Impact of Number of Drug Types on Clinical Outcome in Patients with Acute Hip Fracture.
OBJECTIVES: This study aims to investigate the impact of the number of drug types on clinical outcomes for patients with acute hip fracture.
DESIGNS: This is a retrospective cross-sectional study.
SETTING: A hospital-based database constructed by the Japan Medical Data Center.
PARTICIPANTS: Consecutive patients exhibiting acute hip fractures on admission between April 2014 and November 2017 were included.
MEASUREMENTS: Relationships among the numbers of varying drug types of >/=6 and </=5 as well as clinical outcomes were analyzed in 11,073 patients aged >/=65 years. The primary outcome was defined as the Barthel Index efficiency, with the secondary outcome being the length of hospital stay.
RESULTS: Median Barthel Index scores at admission and discharge were 5 (interquartile range: 5-20) and 50 (interquartile range: 20-85). The Barthel Index efficiency was significantly higher in the group having received 5 or fewer drug variations taken (1.45 +/- 1.77) than in the group receiving 6 or more drug types taken (0.94 +/- 1.18) during hospital stays (p < 0.001). The length of hospital stay was significantly shorter in the group receiving 5 or fewer drug types taken (29.9 +/- 23.8) than in the group having 6 or more drug types taken (44.3 +/- 30.3) during hospital stays (p < 0.001), with the latter number being independently associated with the Barthel Index efficiency and length of hospital stay.
CONCLUSIONS: Number of drug types of 6 or more were associated with lower Barthel Index efficiency and longer lengths of hospital stays.
|ジャーナル名||The journal of nutrition, health & aging|
|投稿者||Maki, H; Wakabayashi, H; Nakamichi, M; Momosaki, R|
|組織名||Hiroki Maki, Department of Pharmacy, Kofu Municipal Hospital, 366 Masutsubochou,;Kofu City, Yamanashi 400-0832, Japan, Tel: +81 55 244 1111; Fax: +81 55 220 2650,;E-mail: email@example.com.|