| アブストラクト | OBJECTIVE: To investigate the impact of the number of drugs on rehabilitation outcomes for patients with acute traumatic brain injury. DESIGN: Retrospective cohort study. SETTING: Hospital-based database created by the Japan Medical Data Center. PARTICIPANTS: Patients with acute traumatic brain injury admitted between April 2014 and November 2017. METHODS: Analysis of relationships among 1-5 and >/= 6 drugs as well as clinical outcomes in 2603 patients. MAIN OUTCOME MEASUREMENTS: The primary outcome was defined as the Barthel index efficiency, and the secondary outcome was Barthel index gain and length of hospital stay. RESULTS: Median Barthel index score on admission was 40. Barthel index efficiency and Barthel index gain were significantly higher in the group that had taken 1-5 drugs than in the group that had taken >/=6 drugs on admission (median: 1.19 vs 0.50, 20.0 vs 10.0). Also, the group that had taken 1-5 drugs had a significantly shorter length of hospital stay than in the group that had taken >/=6 drugs on admission (median 11.0 vs 14.0). Moreover, multiple linear regression analysis showed that having taken >/=6 drugs on admission was independently associated with Barthel index efficiency, Barthel index gain, and length of stay. CONCLUSIONS: Taking>/=6 drugs for acute traumatic brain injury was associated with lower Barthel index efficiency, lower Barthel index gain, and longer length of stay than taking 1-5 drugs. |
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| ジャーナル名 | PM & R : the journal of injury, function, and rehabilitation |
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| 投稿日 | 2020/7/30 |
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| 投稿者 | Yamaoka, Makiko; Chono, Masayuki; Fukumoto, Miki; Watanabe, Tomomi; Fukaya, Takeshi; Momosaki, Ryo |
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| 組織名 | Department of Rehabilitation, Teikyo University School of Medicine University;Hospital, Kawasaki, Japan.;Department of Rehabilitation Medicine, Mie University Graduate School of;Medicine, Mie, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32725880/ |
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